抑郁症是一种情绪障碍，临床表现为情绪低落和兴趣丧失，影响感觉、思维和行动，与创伤性事件、家 庭社会环境、生理遗传易感性密切相关。目前治疗以西药为主，但存在效率低、耐受性差、易复发、易成瘾等 局限性。中医治疗抑郁症疗效显著，与中药的多靶点、多途径的集群效应有关。中草药刺五加具有疏肝解郁、 健脾益气、补肾安神的功效。其活性成分包含了苷类化合物、黄酮类化合物、多糖类、香豆素类衍生物、氨基 酸种类以及多种微量营养元素等，具有调节神经递质、抗氧化、抗炎、免疫调节等作用。本文通过分析近十年 的文献，对刺五加的活性成分及其抗抑郁的作用机制展开深入的探讨与分析，以期更全面地理解刺五加在抑郁 症治疗领域的具体效用，为临床实践与科学研究提供坚实的理论支撑。

Major depressive disorder （MDD） is a mood disorder characterized by persistent low mood and loss of interest， affecting emotions， cognition， and behavior. It is closely associated with traumatic events， familial and social environments，and physiological-genetic susceptibility. Current treatments primarily rely on western medications， which often exhibit limitations such as low efficacy， poor tolerability， high relapse rates， and addiction potential. Traditional Chinese medicine （TCM） has demonstrated significant efficacy in treating depression， attributed to its multi-target and multi-pathway synergistic effects. The Chinese medicinal Acanthopanacis Senticosi Radix et Rhizoma seu Caulis exhibits therapeutic properties including liver-soothing and depression-relieving，spleen-strengthening and qi-replenishing， and kidney-nourishing and mind-calming effects. Its active components comprise glycosides， flavonoids， polysaccharides， coumarin derivatives， amino acids， and various trace nutrients， which exert neuroregulatory，antioxidant，anti-inflammatory，and immunomodulatory effects. By analyzing literature from the past decade， this review comprehensively explores the active constituents of Acanthopanacis Senticosi Radix et Rhizoma and their underlying antidepressant mechanisms，providing a systematic understanding of its therapeutic potential in MDD treatment and offering robust theoretical support for clinical practice and scientific research.

R285.5

国家自然科学基金项目（82274332）。