妊娠期糖尿病（GDM）是影响母婴两代健康的严重代谢性疾病，已成为重大健康问题。中医认为 GDM 病 因包括先天禀赋不足、饮食不节、情志不遂以及后天失养，病机以阴虚内热为主。越来越多临床证据支持肥胖 是 GDM 的独立危险因素之一，脂肪组织葡萄糖代谢稳态失衡与 GDM 发生密切相关。该文在中医整体观思想 指导下，以脂肪分泌的对全身代谢稳态具有调控作用的脂肪细胞因子及棕色脂肪调控葡萄糖代谢为切入点，深 入探讨脂肪功能异常与 GDM 中医病机的相关性及中医药干预的潜在新策略，以期为从脂肪组织糖代谢稳态失 衡角度揭示 GDM 的中医病机科学内涵提供理论依据。

Gestational diabetes mellitus （GDM） is a severe metabolic disorder affecting maternal and infant health and has become a major public health concern. Traditional Chinese Medicine （TCM） attributes the etiology of GDM to insufficient innate endowment， improper diet， emotional disturbances， and postnatal malnourishment， with its pathogenesis primarily rooted in yin deficiency with internal heat. Accumulating clinical evidence supports that obesity is an independent risk factor for GDM，and dysregulation of glucose metabolic homeostasis in adipose tissue is closely linked to GDM development. Guided by the holistic philosophy of TCM， this study focuses on adipokines— metabolically regulatory factors secreted by adipose tissue—and the role of brown adipose tissue in modulating glucose metabolism. It systematically explores the correlation between adipose dysfunction and TCM pathogenesis of GDM，as well as potential novel strategies for TCM-based interventions. This work provides a theoretical foundation for deciphering the scientific connotation of TCM pathogenesis in GDM from the perspective of adipose tissue glucose metabolism homeostasis imbalance.

R714.25

广东省中医药局科研项目（20241162）；广东药科大学2021年校级一流本科课程立项建设项目（广药大教2021〔3〕 号）；广东药科大学 中医学重点学科建设项目2021年度科研项目（ZY2021T04）；国家自然科学基金青年项目（81703906）。