抑郁症是一种严重危害人类健康的精神疾病，其致病因素多，病理机制复杂。中药复方治疗抑郁症具有 多成分、多靶点及个体化治疗的特点。根据中医辨证分型，抑郁症可分为六个类型，包括肝郁气滞型、肝郁脾 虚型、肝郁化火型、心脾两虚型、心肾不交型和肾虚肝郁型。该文根据上述辨证分型系统整理近十年来治疗抑 郁症的相关中药复方，并从药理研究和临床研究两个方面进行系统阐述。中药复方可通过调节炎症因子、神经 递质、神经可塑性、信号传导通路、HPA 轴等多途径发挥抗抑郁作用，在临床应用中显示出较好的治疗效果。

Depression is a mental disease that seriously endangers human health，with many pathogenic factors and complex pathological mechanisms. The treatment of depressive disorders with Chinese herbal compounds has the characteristics of multi-component， multi-target and individualised treatment. According to the traditional Chinese medicine （TCM） syndrome differentiation and classification， depression can be divided into six types： liver depression and qi stagnation type，liver depression and spleen deficiency type，stagnated liver qi transforming in to fire type， heart-spleen deficiency type， incoordination between heart and kidney type and kidney deficiency liver depression type. Based on the above syndrome differentiation and classification，this article systematically collated the relevant Chinese herbal compounds for the treatment of depression in the past decade，and systematically elaborated them from both pharmacological and clinical studies. The TCM prescriptions can exert antidepressant effects by regulating inflammatory factors， neurotransmitters， neuroplasticity， signaling pathways， HPA axis and other pathways，and have shown ideal therapeutic effects in clinical applications.

R285.5；R285.6

国家自然科学基金项目（82074505，82374547）；广东省基础与应用基础研究基金项目（2023A1515011835，2022A1515010230， 2022A1515220121）