阿尔茨海默病（AD）是一种常见的神经退行性疾病，具有患病率高、并发症广、社会及家庭负担重的特点，其病理特征主要表现为脑内含有以 β-淀粉样蛋白（Aβ）为主要的成分沉积于细胞外的神经炎性斑和由过度磷酸化 Tau 蛋白在细胞内聚积形成的神经原纤维缠结等。近年研究显示，线粒体功能障碍在 AD 的发病机制中扮演关键的角色。线粒体质量控制（MQC）系统是维护线粒体功能和结构稳定的重要机制，包括线粒体生物发 生、线粒体动力学、自噬及钙稳态调节等。中医药通过调控 MQC 在防治 AD 中展现出独特的优势和潜力。因此，该文系统综述中医药靶向调控 MQC 防治 AD 的研究进展，以期为 AD 的防治提供新的策略和方向。

Alzheimer’s disease （AD） is a common neurodegenerative disease， which is characterized by high prevalence，wide-ranging complications，and heavy social and family burdens. Its pathological features mainly include extracellular deposition in the brain of neuroinflammatory plaques mainly composed of beta amyloid protein （Aβ），and intracellular accumulation of neurofibrillary tangles formed by hyperphosphorylated Tau protein. Recent studies have shown that mitochondrial dysfunction plays a key role in the pathogenesis of AD. The mitochondrial quality control（MQC） system is an important mechanism for maintaining mitochondrial function and structural stability，including mitochondrial biogenesis， mitochondrial dynamics， autophagy， and regulation of calcium homeostasis. Traditional Chinese medicine has demonstrated unique advantages and potential in the prevention and treatment of AD by regulating MQC. Therefore，this article systematically reviews the research progress on targeted regulation of MQC by traditional Chinese medicine for the prevention and treatment of AD， which provides new strategies and directions for the prevention and treatment of AD.

R285.5

国家自然科学基金项目（81573919）；国家中医药管理局中医药科学技术研究专项课题（GZY-KJS-2021-017）；河南省重点研发专项项目（221111310500）