时间与空间是自然状态下事物所具备的最基本属性，生理状态下脏腑阴阳气血的盛衰变化及病理过程中疾病的复杂征象无不与时空发展有关。结合胃的生理结构与“炎-癌”转化癌前病变发生、进展特点及病理变化，其过程符合时空窗的理论。基于时空窗理论，认为“虚、瘀、毒”致病因素是胃“炎-癌”转化恶性进展至胃癌时间化的基本特征，“中焦瘀毒互结”病机是胃“炎-癌”转化空间化的普遍规律。基于时空窗视角构建以胃癌前病变诊断、预防、治疗为导向的理论框架，采用健脾、化瘀、解毒的治则治法动态施治，中医药阻断胃“炎-癌”转化具有独特优势。该文重点探析不同时空下胃“炎-癌”转化的病理特点及其临床治疗，为胃癌的防治路径提供新内涵，也为治疗“炎-癌”转化类疾病提供范例。

Time and space are the most fundamental attributes of any things in their natural state. The fluctuations of the yin，yang，qi，and blood in the physiological state of the viscera，as well as the complex manifestations of diseases in the pathological process， are all related to the development of time and space. The physiological structure of the stomach，the characteristics of the occurrence and progression of precancerous lesions in the "inflammation-cancer" transformation，and the pathological changes are in line with the theory of the temporal window. Based on the theory of the temporal window，it is believed that the pathogenic factors of "deficiency，blood stasis，and toxicity" are the basic characteristics of the temporal variation in the malignant progression of the "inflammation-cancer" transformation to gastric cancer，and the pathogenesis of "toxicity and blood stasis of middle burner" is the universal law of the spatial variation of the "inflammation-cancer" transformation. Constructing a theoretical framework oriented towards the diagnosis，prevention，and treatment of precancerous gastric lesions from the perspective of the temporal window，and dynamically applying the treatment principles and methods of strengthening the spleen， resolving blood stasis， and detoxifying，traditional Chinese medicine has unique advantages in blocking the "inflammation-cancer" transformation of the stomach. This paper focuses on analyzing the pathological characteristics of the "inflammation-cancer" transformation in different times and spaces and its clinical treatment， aiming to provide new connotations for the prevention and treatment of gastric cancer and offer a model for the treatment of diseases with "inflammation-cancer" transformation.

R285.6

国家自然科学基金面上项目（82374343）；广东省基础与应用基础研究基金项目（2023A1515011107，2024A1515030250）；广州市科学技术局基础研究计划（2023A04J1169）；省部共建中医湿证国家重点实验室开放课题面上项目（SZ2022KF17）；2023年广东高校科研平台和项目重点领域项目（2023ZDZX2013）； 广州中医药大学青年创新拔尖人才团队培育揭榜挂帅项目（A1-2601-24-414-110Z59）；国家中医药管理局中医药创新团队及人才支持计划项目（ZYYCXTD-C-202208）。