目的 研究黄芪建中汤颗粒的最佳成型工艺。方法 以制备软材的难易程度、制粒的难易程度、颗粒成型性及溶化性为评价指标，正交试验法优化黄芪建中汤颗粒的成型工艺；以颗粒成型性、颗粒含水量为评价指标，筛选湿颗粒的干燥温度。结果 黄芪建中汤颗粒的最佳成型工艺：药物∶可溶性淀粉∶糊精为 1∶1∶1，润湿剂为 75% 乙醇，其用量为 28%；湿颗粒的最佳干燥温度：60 ℃。结论 该研究优化的黄芪建中汤颗粒的成型工艺，其方法合理可行，可为黄芪建中汤颗粒的制备提供科学依据。

Objective To study the best forming process of Huangqi Jianzhong Decoction Granules. Methods Taking the difficulty of preparing soft materials and granulation，as well as formability and solubility of particles as evaluation indexes，this paper carried out orthogonal test to optimize the forming process of particles. The drying temperature of wet particles was screened by taking particle formability and water content as evaluation indexes. Results The optimum forming process of Huangqi Jianzhong Decoction Granules was as follows：the ratio of drug to the starch to the dextrin was 1∶1∶1，wetting agent was 75% ethanol，and its dosage was 28%. The optimum drying temperature of wet granules was 60 ℃. Conclusion In this study，the forming process of Huangqi Jianzhong Decoction Granules was optimized. The method was reasonable and feasible，which could provide scientific basis for the preparation of Huangqi Jianzhong Decoction Granules.

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国家自然科学基金项目 （81703683）；吉林省科技厅项目 （YDZJ202301ZYTS188，YDZJ202101ZYTS074）；吉林省人社厅厅项目 （2023QN35）；吉林省教育厅项目 （JJKH20230546KJ）；吉林省大学生创新创业训练计划项目 （X202213706009）