糖尿病肾病（DN）的发病机制相当复杂，铁死亡作为一种新发现的细胞死亡方式成为近年来的研究热点， 而 DN 与铁死亡密切相关。System Xc- -GSH-GPX4 轴失活、铁过载、脂质过氧化及线粒体功能障碍等因素在 DN 铁死亡发生发展中具重要作用，抗氧化蛋白可能是治疗 DN 铁死亡的潜在靶点。通过激活 GPX4、Nrf2、 Sirtuin 家族蛋白及铁蛋白等抗氧化蛋白，可以通过不同途径与相互作用缓解铁死亡的发生发展。中药具有多成 分、多靶点、多途径整体调节的特点，中药活性成分及中药复方通过增强抗氧化蛋白表达，对改善 DN 肾损伤 和铁死亡具有潜在应用价值，为延缓 DN 的进展提供了新的研究方向。

The pathogenesis of diabetic nephropathy （DN） is very complex. Ferroptosis as a kind of new way of cell death has become a research hotspot in recent years. It is widely known that DN is closely related to ferroptosis. Deactivation of system Xc- -GSH-GPX4 axis，iron overload，lipid peroxidation and mitochondrial dysfunction play important role in occurrence and development of ferroptosis of DN，antioxidant protein may be a potential target for the treatment of ferroptosis of DN. Different pathways and interactions may alleviate the occurrence and development of ferroptosis by activating antioxidant protein such as GPX4，Nrf2，Sirtuin family protein and ferritin. Traditional Chinese medicine （TCM） has the characteristics of multi-component， multi-target and multi-pathway overall regulation. The active components and compounds of TCM have potential application value in improving renal injury and ferroptosis of DN by enhancing the expression of antioxidant protein，which provides a new research direction for delaying the progress of DN.

R285.5

上海市卫生健康委员会科研发展基金（202150030）