目的 采用一测多评（QAMS）法同时检测松龄血脉康胶囊中莽草酸、儿茶素、槲皮素、山柰酚、异鼠李 素、3’-羟基葛根素、葛根素、3’-甲氧基葛根素、大豆苷和染料木素含量，建立加权优劣解距离（TOPSIS）与 灰色关联度（GRA）融合模型对 15 批样品进行质量评价。方法 采用高效液相色谱（HPLC）法，以山柰酚为内参 物，计算各成分相对校正因子及含量，与外标法实测值对比验证 QAMS 法可行性；采用化学计量学对含量结 果进行分析，挖掘松龄血脉康胶囊质量差异标志物。以各成分 VIP 值为权重，通过加权 TOPSIS 与 GRA 融合 模型对样品质量进行差异性分析。结果 一测多评法与外标法结果无显著差异；15 批样品聚为 3 类，葛根素、 3’-羟基葛根素、槲皮素、3’-甲氧基葛根素和莽草酸为松龄血脉康胶囊的质量差异标志物；加权 TOPSIS 与 GRA 融合模型分析结果显示，不同时期生产的松龄血脉康胶囊存在一定质量差异。结论 一测多评、加权 TOPSIS 与 GRA 融合模型可用于松龄血脉康胶囊的质量综合评价。

Objective To simultaneously determine of shikimic acid， catechin， quercetin， kaempferol， isorhamnetin，3’-hydroxypuerarin，puerarin，3’-methoxypuerarin，daidzin and genistein in Songling Xuemaikang Capsules by quantitative analysis of multi-components by single-marker （QAMS），and to establish fusion model of weighted technique for order preference by similarity to an ideal solution （TOPSIS） and grey relational analysis （GRA） for evaluating the quality of 15 batches of samples. Methods HPLC method was used to calculate the relative correction factor and content of each component，using kaempferol as internal reference. The feasibility of QAMS method was verified by comparing with the measured value of external standard method. The content results were analyzed by chemometrics to explore the quality difference markers of Songling Xuemaikang Capsules. Taking the VIP value of each component as the weight，we performed differential analysis on sample quality through fusion model of weighted TOPSIS and GRA. Results There was no significant difference between the results of QAMS and external standard method. The 15 batches of samples were clustered into three categories. Puerarin，3’-hydroxypuerarin， quercetin， 3’-methoxypuerarin and shikimic acid were the quality difference markers of Songling Xuemaikang Capsules. The results of fusion model of weighted TOPSIS and GRA showed that there were some quality differences in Songling Xuemaikang Capsules produced at different times. Conclusion The hybrid model combining QAMS， weighted TOPSIS and GRA can be used for the comprehensive evaluation of the quality of Songling Xuemaikang Capsules.

R284.1

湖北省中医药科研立项青年人才项目（ZY2019Q014）