子宫内膜异位症 （Endometriosis，EMs） 是一种炎症性疾病，炎症微环境是其发生发展的关键环节。中医 学认为“血水同病”，即湿瘀互结是 EMs 的关键病机，炎症微环境是 EMs 湿瘀状态的体现，正气不足导致水 湿内生，瘀血停滞是湿瘀互结状态形成的基础。从现代分子生物学阐释 EMs 的发病机制，巨噬细胞调控的炎 症微环境是“湿”形成的基础，巨噬细胞参与的血管生成是“血瘀”形成的关键。探讨 EMs 炎症微环境与 “血水同病”理论的微观联系，有助于从新的视角阐明 EMs 的中医病机内涵；以巨噬细胞为靶点，可为 EMs 的中医证治提供有益参考。

Endometriosis （EMs） is a chronic inflammatory disease. It has been proved that inflammatory microenvironment is the key role in EMs occurance and development. Chinese medicine posits that the theory of “same disease of blood and water”，which generally refers to “intermingling dampness and blood stasis”，serves as a crucial pathogenesis in EMs. The inflammatory microenvironment is the main manifestation of dampness and blood stasis in EMs，while the insufficiency of vital qi results in endogenous dampness. The stagnation of blood stasis serves as the foundation for the formation of intermingling dampness and blood stasis. Based on contemporary theories in molecular biology，the macrophage-mediated inflammatory microenvironment serves as the foundation for the formation of dampness，while the participation of macrophages in angiogenesis is crucial for the formation of blood stasis. Investigating the intrinsic connection between the inflammatory microenvironment in EMs and the theory of “same disease of blood and water” can contribute to a better understanding of the pathogenesis of EMs from a novel perspective. Remodeling of the inflammatory microenvironment in endometriosis by targeting macrophages may provide a new strategy for EMs treatment.

R285.5；285.6

国家自然科学基金-青年科学基金项目 （82305295）；广东省自然科学基金项目 （2023A1515011109）；广东省自然科学基金-粤穗联合 青年基金项目（2022A1515110697）；广州市科技局基础与应用基础项目-青年基金项目（2023A04J1130）；广东省中医药局科研基金项目 （20231018）；国家中医药管理局第五批全国中医临床优秀人才研修项目 （国中医药人教函[2022]1号）