目的 以数据挖掘的方法分析阮岩教授治疗儿童变应性鼻炎的组方用药规律，为治疗儿童变应性鼻炎的 临床实践及成药研发提供参考。方法 收集阮岩教授治疗儿童变应性鼻炎的门诊医案，运用 Microsoft Excel 2010 软件进行频数统计，运用 SPSS Clementine 12.0软件进行关联规则分析、聚类分析、因子分析等数据挖掘 方法，获得药物的使用频次及药物之间的关联规则，分析处方中的用药组方规律。结果 共收集处方 308 首， 中医证型分布以肺气虚寒证和肺脾气虚证为主，涉及中药 80 种，高频中药以解表药和补气药为主，药物性味 以辛甘温为主，多归肺脾胃经；聚类分析得到 4 个潜在的核心基础方，因子分析得到 5 个核心药方。结论 阮 岩教授临床治疗儿童变应性鼻炎以宣肺通窍、祛风散寒、健脾益气为基本治疗方法，在变应性鼻炎发作期多以 驱邪为主，宣肺通窍、祛风散寒；缓解期则以“治病求本”为主要原则，从改善儿童体质入手，补肺健脾，以 治其本。

Objective To analyze and discuss the medication rule of professor Ruan Yan in the treatment of children with allergic rhinitis by using data mining method，and to provide reference for the clinical research and patented drugs development for the treatment of children with allergic rhinitis. Methods The outpatient medical records of professor Ruan Yan for the treatment of children with allergic rhinitis were collected. Microsoft Excel 2010 software was used for frequency statistics. SPSS Clementine 12.0 software was used for association rule analysis，cluster analysis and factor analysis to obtain the data. The frequency of use of various drugs and the association rules between drugs were obtained. Then the medication rules in professor Ruan Yan’ s prescription were analyzed. Results A total of 308 Chinese medicine compounds were included，involving 80 kinds of Chinese medicines，among which relieving drugs and qi-invigorating herbs were high-frequently used. The distribution of traditional Chinese medicine syndrome types was mainly characterized by lung-qi deficiency-cold syndrome and lung-spleen qi deficiency syndrome. The medicinal properties were mainly spicy，warm and sweet，and most of them belonged to the lung， spleen and stomach meridians. Five core prescriptions were extracted by factor analysis. Four drug combinations were obtained by systematic cluster analysis. Conclusion Ventilating lung and opening the orifices，expelling wind and removing cold，strengthening the spleen and replenishing qi are basic therapeutic principles for professor Ruan Yan in the treatment of children with allergic rhinitis. The treatment mainly focused on dispelling evil，ventilating lung and opening the orifices， expelling wind and removing cold during the acute stage of allergic rhinitis. In the remission period，according to the principle of “treating disease must be based on its origin”，the treatment should enhance children’ s physical fitness，tonify lung and strengthen spleen，thereby reducing recurrence.

R285.6

国家自然科学基金项目 （82274590， 82305325，81974581）；广东省基础与应用基础研究基金项目 （2021A1515110446） ；广州市科技 基础与应用基础研究项目 （202201011211） ；2020 年阮岩省名中医传承工作室项目 （2100600145）；国家中医药管理局2023年中医药循证能力提升 项目；广州市科技计划项目 （202201020308）。