目的 观察奥瑞凝胶的抗炎作用及其对反流性食管炎（RE）模型大鼠白细胞介素-8（IL-8）的影响。方法 以二甲苯所致小鼠耳肿胀、白细胞游走抑制及棉球肉芽肿为炎症指标，观察奥瑞凝胶的抗炎作用；用半幽门结扎加贲门肌切开术复制RE大鼠模型，观察奥瑞凝胶对RE食管黏膜组织中IL-8的影响。结果 与模型组比较，奥瑞凝胶高、中、低剂量组能明显抑制耳肿胀（P＜0.05）和白细胞游走（P＜0.05），肉芽组织含量显著降低（P＜0.05）；奥瑞凝胶各组组织中IL-8含量明显下降（P＜0.05）。结论 奥瑞凝胶具有明显的抗炎作用，其作用机制可能与降低食管组织中IL-8的含量有关。

Objective To observe the anti-inflammatory effect of Ori gel and its effect on interleukin 8（IL-8） of reflux esophagitis（RE） rats. Methods The anti-inflammatory effect of Ori gel was evaluated by observing xylene-induced mouse ear swelling，rat white blood cell migration inhibition，and cotton-ball induced rat granuloma. Half-pylorus ligation plus cardiomyotomy was used to establish RE rat model，and then the effect of Ori gel on the IL-8 content in esophageal mucosa tissue homogenate of RE rat model was observed. Results Compared with the model group，high-，medium- and low-dose Ori gel could relieve the ear swelling（P＜0.05），inhibit white blood cell migration（P＜0.05），reduce granulation tissue（P＜0.05），and decrease the content of IL-8 obviously（P＜0.05）. Conclusion Ori gel has significant anti-inflammatory effect，and its mechanism may be related to lowering the content of IL-8 in the esophageal tissue.

R285.5

河南省科技厅重点科技攻关项目（082102330025）；河南中医学院科技创新人才基金（2013XCXRC05）；河南中医学院科技创新团队基金（2011XCXTD04）。