目的 研究仁青常觉对N-甲基-N'-硝基-N-亚硝基胍（MNNG）致慢性萎缩性胃炎大鼠的治疗作用，并探讨其作用机制。方法 大鼠自由饮用8周170 mg•L-1 MNNG水溶液制备大鼠慢性萎缩性胃炎（CAG）模型，并随机分为：模型组，阳性药对照组（胃复春组），仁青常觉高、中、低剂量组，每组8只，除模型组外分别灌胃给予相应浓度药物进行治疗，连续给药8周。另取8只正常大鼠设为空白对照组。于末次给药后麻醉解剖处死大鼠，观察各组大鼠胃黏膜病理改变，并测定胃游离黏液量、pH值及血清中肿瘤坏死因子-α（TNF-α）、丙二醛（MDA）、一氧化氮（NO）水平。结果 与模型组比较，仁青常觉各剂量组大鼠胃黏膜组织病理形态均有不同程度的改善，血清中TNF-α、NO、MDA水平及胃游离黏液pH值显著降低，胃游离黏液量显著增多（P＜0.05，P＜0.01）。结论 仁青常觉能有效治疗MNNG所致GAG，增加胃游离黏液量，其作用机制可能与降低TNF-α、MDA、NO水平有关。

Objective To observe the effect of Renqing Changjue on MNNG-induced chronic atrophic gastritis in the rats. Methods The rats in the model group were fed with 170 mg•L-1 MNNG freely in drinking water for eight weeks. Meanwhile the rats of the control group were only fed with drinking water. After eight weeks the model rats were randomly divided into model control group，positive drug group，and high-，middle- and low- dose groups of Renqing Changjue. The rats were given the corresponding drugs orally for 8 weeks. At the end of the last administration，the pathological change of gastric mucosa was observed in the rats. Gastric free mucus amount，PH value and TNF-α，NO，MDA concentrations were detected in the rats. Results Compared with those of the model group，the gastric mucosa pathological changes of the rats were improved in Renqing Changjue groups，and their serum TNF-α，MDA，NO concentrations and PH value in the gastric free mucus were decreased significantly（P＜0.05），and the gastric free mucus amount of the rats was increased. Conclusions Renqing Changjue can treat MNNG-induced chronic atrophic gastritis effectively and increase the amount of free mucus，and its the rapeutic mechanism may be related to reducing the TNF-α，MDA，NO levels in the serum.

R285.5

藏医药产业技术创新服务平台（2013-488）。