目的 建立高效液相法测定消脂胶囊中丹参酮ⅡA和丹酚酸B含量的方法。方法 采用Grace Smart C18（4.6 mm×250 mm，5 μm）色谱柱；丹参酮ⅡA以甲醇-水（75∶25）为流动相等度洗脱，波长为270 nm；丹酚酸B以甲醇-甲酸-水（40∶1∶59）为流动相等度洗脱，波长为286 nm；流速为1.0 mL·min-1；柱温为30 ℃；进样量为10 μL。结果丹参酮ⅡA浓度在0.004～0.04 mg·L-1范围内呈良好的线性关系，平均回收率98.21 %（RSD 为2.817 %，n=6）；丹酚酸B在0.03～0.3 mg·L-1范围内呈良好的线性关系，平均回收率98.86 %（RSD为2.119 %，n=6）。结论 该法快速，简便易行，结果可靠，专属性强，可作为消脂胶囊的质量控制指标。

Objective To develop a high performance liquid chromatography（HPLC） method for simultaneous determination of tanshinoneⅡA and salvianolic acid B in Xiaozhi Capsule. Methods Samples were analyzed on Grace Smart C18（4.6 mm×250mm，5 μm）. The detection of tanshinoneⅡA was with a mobile phase of methanol-water（75∶25） for isocratic elution and a detection wavelength of 270 nm. Salvianolic acid B was detected with a mobile phase of methanol - methanoic acid-water（40∶1∶59） for isocratic elution and a detection wavelength of 286 nm. The flow rate was 1.0 mL·min-1，temperature of column was set at 30 ℃ and injection volume was 10 μL. Results TanshinoneⅡA showed good linearity in the range of 0.004~0.04 mg·L-1，and the recovery was 98.21 %（RSD=2.817 %，n=6）. Salvianolic acid B showed good linearity in the range of 0.03~0.3 mg·L-1，and the recovery was 98.86 %（RSD=2.119 %，n=6）. Conclusion The established method is rapid，practical and accurate，and is suitable for the quanlity control of Xiaozhi Capsule.

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