目的 观察金荞麦提取物对慢性阻塞性肺病（COPD）大鼠模型的作用及机制。方法 水提和醇提法制备金荞麦提取物；改良烟熏法复制SD大鼠COPD模型，实验分为正常组，模型组，金荞麦水提取物低、高剂量组，金荞麦醇提取物低、高剂量组。药物干预后，放射免疫法测定血清肿瘤坏死因子-α（TNF-α）、白介素-6（IL-6）、白介素-8（IL-8）、Ⅲ型前胶原肽（PⅢ）、转化生长因子（TGF-β1）含量的变化，光镜观察肺组织病理形态学。结果 模型组大鼠血清TNF-α、IL-6、IL-8、PⅢ、TGF-β1含量较正常组明显升高（P＜0.01），肺组织病理损伤明显；金荞麦提取物可显著降低上述异常升高的指标（P＜0.05）、改善肺组织病理损伤，其中金荞麦醇提物高剂量组作用最明显（P＜0.01）。结论 金荞麦提取物能抑制COPD大鼠的炎症反应，改善肺组织的病理损伤。

Objective To study the effect of the extract of Fagopyrum dibotrys（FD） on chronic obstructive pulmonary disease（COPD） rats and to explore the therapeutic mechanism for COPD. Methods FD water-extract and ethanol- extract of were prepared. COPD in SD rats was induced by modified smoking method. SD rats were randomly divided into normal group，model group，low- and high-dose FD water-extraction groups，low- and high-dose FD ethanol-extraction groups. After drug intervention，the serum levels of tumor necrosis factor alpha（TNF-α），interleukin 6（IL-6），IL-8，precollagen peptide III（PIII），transforming growth factor beta 1（TGF-β1） were detected by radioimmunoassay method. Histopathological changes of lung were also observed. Results Compared with the normal group，the serum levels of TNF-a，IL-6，IL-8，PIII，and TGF-β1 in the model group were increased significantly（P＜ 0.01）. The lung pathological injury was obvious in the model group. FD extract significantly decreased the abnormal rising of the above indexes，and improved the lung histopathological changes in rats，especially in high-dose FD ethanol-extraction group（P＜ 0.01）. Conclusion FD extract can inhibit the inflammatory response in COPD rats，and improve the lung histopathological changes.

R285.5

江苏省中医药局中医药科技专项（LB09113）。