目的 观察玉壶汤对db/db小鼠的降糖调脂作用，并比较党参代替人参后新方与原方的药效。方法 取12周龄自发性2型糖尿病db/db小鼠，将血糖值大于16.7 mmol·L-1的小鼠按血糖水平分层随机分为模型组、玉壶汤组、玉壶汤新方组、消渴丸组，另设野生型雄性db/db小鼠为正常对照组。给药8周后，以生化仪检测小鼠血糖、总胆固醇（CHOL）、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、低密度脂蛋白胆固醇（LDL-C）；酶标仪检测小鼠血清超氧化物歧化酶（SOD）、丙二醛（MDA）、胰岛素、白介素-6（IL-6）含量。结果 与模型组比较，玉壶汤组小鼠血清中血糖、CHOL、TG、MDA和IL-6含量显著降低，SOD活力、胰岛素水平显著升高（P＜0.05，P＜0.01）；玉壶汤新方组小鼠血清中血糖、CHOL、TG和IL-6含量显著降低，SOD活力、胰岛素水平显著升高（P＜0.05， P＜0.01）。结论 玉壶汤对2型糖尿病有较好的降糖调脂作用，以党参代替人参入方后的新方与原方的药效相当。

Objective To study the pharmacodynamics effects of Yuhu Decoction（YD） on lowering the level of blood glucose and lipid in db/db mice，and to compare the pharmacodynamic actions of the original decoction with the decoction with Radix Ginseng replaced by Radix Codonopsitis. Methods Spontaneous type 2 diabetes db/db mice aged 12 weeks with blood glucose level over16.7 mmol·L-1 were randomized into model group，YD group，modified YD group（YD with Radix Ginseng replaced by Radix Codonopsitis），and Xiaoke Pills group according to the blood glucose level. Wild type male db/db mice served as the normal control. After medication with the corresponding drug for 8 weeks，blood glucose and total cholesterol（TC），triglyceride（TG），high-density lipoprotein cholesterol（HDL-C） and low-density lipoprotein cholesterol（LDL-C） were detected by biochemical analyzer，Serum levels of superoxide dismutase（SOD），malondialdehyde（MDA），insulin and interleukin 6（IL-6） were detected by microplate reader according to kit method. Results Compared with the model group，the levels of glucose，TC，TG，MDA and IL-6 in blood were decreased，and SOD activities and insulin level were increased in YD group（P＜0.05，P＜0.01）；the observation indexes except the MDA showed the same changes in modified YD group（P＜0.05，P＜0.01）. Conclusion Yuhu Decoction has the effects of lowering the level of blood glucose and lipid in type 2 diabetes db/db mice，and the effect keeps steady when Radix Ginseng in the decoction is replaced by Radix Codonopsitis.

R285.5

浙江省科技计划重点项目（2004F12016）；浙江省科技厅重点实验室建设项目（2012F10002）。