目的 制备离子敏感型熊胆眼用即型凝胶，并对其凝胶特性进行评价。方法 采用单因素实验法优选凝胶基质以及凝胶增强剂，使用优选处方制备即型凝胶，并对其质量（渗透压、黏度、体外释放以及眼部滞留能力）进行考察。结果 结冷胶（Gelrite）和羧甲基纤维素钠（CMC-Na）比例为0.6 %∶0.3 %时制备凝胶效果较好；所制备的熊胆凝胶制剂与熊胆滴眼液比较，用药后黏度显著增加，具有较好的缓释特性；在用药部位停留时间较长，眼部滞留能力显著增强。结论 制得的熊胆眼用即型凝胶具有良好成型性，符合即型凝胶的要求。

Objective To preparae ion-sensitive Xiongdan ophthalmic in-situ gel，and to evaluate its quality. Methods Using single factor experiment method，we optimized gel matrix and the preparation of the in-situ gel，and evaluated the quality of the in-situ gel by measuring the osmotic pressure，viscosity，in-vitro release，and eye retention capacity. Results When the ratio of Gelrite and sodium methoxycellulose（CMC-Na） was 0.6 %∶0.3 %，the gel preparation had good formability. Compared with the eye drops，the in-situ gel had increased viscosity and satisfactory delayed release，and had better eye retention capacity. Conclusion The prepared Xiongdan ophthalmic in-situ gel has good formability，and is in accordance with the requirement of the in-situ gel.

R284.1