目的 建立骨痹颗粒的质量标准。方法 采用薄层色谱（TLC）法对该制剂中桑寄生、续断、骨碎补进行定性鉴别；采用高效液相色谱法测定该制剂中续断的有效成分川续断皂苷Ⅵ的含量。结果 桑寄生、续断、骨碎补的TLC别专属性强；川续断皂苷Ⅵ在0.24～15.33 μg范围内呈良好的线性关系，平均回收率为98.36 %，RSD为1.09 %（n=9）。结论 该定性、定量检测方法简便可行、专属性强、重现性好、灵敏度高，可作为骨痹颗粒的质量控制标准。

Objective To establish the quality standard for Gubi Granules. Methods Herba Taxilli，Radix Dipsaci，Rhizoma Drynariae in Gubi Granules were identified by thin layer chromatography（TLC），and the content of asperosaponin Ⅵ of Radix Dipsaci was determined by high performance liquid chromatography（HPLC）. Results TLC could identify Herba Taxilli，Radix Dipsaci，Rhizoma Drynariae effectively. A good linearity of asperosaponin Ⅵ was in the range of 0.24 ~ 15.33 μg. The average recovery was 98.36 %，and RSD was 1.09 %（n=9）. Conclusion The established methods are simple，specific，reproducible，and sensitive，and they can be used for the quality control of Gubi Granules.

R284.1

江苏省科技支撑计划——社会发展项目（BE2011847）； 产学研联合创新资金——前瞻性联合研究项目（BY2012036）