肠易激综合征（IBS）患者肠内存在免疫屏障异常，进而导致机械屏障异常，而IBS患者也存在紧密连接蛋白（TJs）调节的肠上皮机械屏障的 异常。TJs属于跨膜蛋白，可通过直接和间接影响其信号通路而改变其的结构和功能，其中内源性细胞因子是其主要影响因素。植物药可通过直接和间接作用影响TJs的结构 和功能，改善肠上皮屏障的完整性，为IBS的治疗提供了研究思路。

Patients with irritable bowel syndrome（IBS） have abnormal enteral immune barrier，which further leads to mechanical barrier dysfunction. IBS patients also have abnormal intestinal epithelial mechanical barrier dysfunction regulated by tight junction protein（JTs）. JTs belong to the transmembrane protein family. Their structure and function can be changed by direct or indirect effects on related signaling pathways ，among which endogenous cytokines are the major influencing factors. Herbal medicines can affect the structure and function of JTs through direct and indirect effects，and improve the intestinal epithelial barrier integrity，which provides novel research ideas for the treatment of IBS.

R285.5

江苏省中医药局科技项目（LZ11202）；江苏省自然科学基金青年基金项目（BK20140959）。