目的 评价芒硝用于结肠镜检查清洗肠道的临床效果和安全性。方法 采用单中心、随机、双盲、平行对照方法，将48例患者按随机编码表方法 分为芒硝组和复方聚乙二醇电解质散（和爽）组。以肠道残余粪水量和肠道泡沫量为主要评价指标，由内窥镜医师进行评价；以问卷调查患者服用药物后的伴随症状为次要 指标。结果 芒硝组肠道残余粪水量明显少于和爽组，差异有统计学意义（P =0.010）；肠道泡沫明显少于和爽组，差异有统计学意义（P =0.022）。服用芒硝后伴随症状 以腹痛为主，未发现明显的不良反应，但给药后至排便的时间较和爽组明显延长（P =0.0007）。结论 芒硝清洗肠道效果优于和爽，且有良好的耐受性和安全性，但给药后 至排便的时间较长。

Objective To evaluate the clinical effects and safety of Natrii Sulfas for bowel cleansing before colonoscopy measurement. Methods A single-center，randomized，double-blind，paralleled-control trial was carried out in 48 patients. The patients were randomized to Natrii Sulfas group and polyethylene glycol（PEG） group. With the amount of intestinal residue fluid and intestinal foam as the primary outcomes，colonoscopy physicians who were blinded to the protocol evaluated the quality of bowel preparation. The accompanied symptoms of patients showed by the questionnaires were used as the secondary outcomes. Results Natrii Sulfas group had lower amount of intestinal residue fluid（P= 0.010） and intestinal foam amount（P=0.022） than those in PEG group. The accompanied symptoms in Natrii Sulfas group were mainly shown as abdominal pain，and the time from medication to defecation was significantly longer than that in PEG group. Conclusion Natrii Sulfas is more effective and safer than PEG in bowel cleansing，and has good tolerability，but the time from medication to defecation is longer than PEG.

R285.6