目的 探讨胆胃双和汤对胆汁反流性胃炎大鼠模型的防治作用及对胃泌素（GAS）、胃动素（MTL）、瘦素（LEP）、前列腺素E2（PGE2）、肿瘤 坏死因子α（TNF-α）、白介素-1β（IL-1β）含量的影响。方法 自制反流液给大鼠灌胃复制胆汁反流性胃炎大鼠模型，以铝碳酸镁片和枸橼酸莫沙比利分散片合用为对照 ，观察胆胃双和汤对胆汁反流性胃炎大鼠防治作用及对GAS、MTL、LEP、PGE2、TNF-α、IL-1β含量和胃黏膜病理组织学改变的影响。结果 胆汁反流性胃炎模型大鼠胃黏膜 出现炎症及变性坏死，且GAS、MTL、LEP、PGE2含量降低，TNF-α、IL-1β含量升高（P＜ 0.05，P＜ 0.01）；胆胃双和汤能升高GAS、MTL、LEP、PGE2含量，降低TNF-α、 IL-1β含量，减轻胃黏膜损伤。结论 胆胃双和汤具有防治胃黏膜损伤的作用，可能与调节GAS、MTL、LEP、PGE2、TNF-α、IL-1β的含量有关。

Objective To observe the protective and therapeutic effect of Danwei Shuanghe Decoction for bile reflux gastritis rats，and to explore its influence on gastrin（GAS），motilin（MTL），leptin（LEP），prostaglandin E2（PGE2），tumor necrosis factor alpha（TNF-α），and interleukin-1 beta（IL-1β） contents in rats. Methods SD rats were given self-made reflux liquid orally to induce experimental bile reflux gastritis.With the combination of Hydrotalcite and Mosapride Citrate Dispersible Tablets as the positive control，we observed the protective and therapeutic effect of Danwei Shuanghe Decoction for bile reflux gastric mucosa. Result In the model rats，inflammation，degeneration and necrosis occurred in gastric mucosa，GAS，MTL，LEP and PGE2 contents were decreased，and TNF-α and IL-1β contents were increased（P＜ 0.05 or P＜ 0.01）. Danwei Shuanghe Decoction showed counteraction on the above changes. Conclusion Danwei Shuanghe Decoction exerts protective and therapeutic effect for bile reflus gastritis，and its mechanism may be related weth the regulation of GAS，MTL，LEP，PGE2，TNF-α and IL-1β contents.

R285.5

国家自然科学基金项目（81102885）；江苏省中医药局科技项目（LZ11194）；江苏高校优势学科建设工程资助项目。