目的 观察干姜、肉桂、丁香、吴茱萸、小茴香、高良姜、荜茇、荜澄茄、花椒、胡椒10味温中散寒中药对胃实寒证大鼠甲状腺机能及肠系膜 微循环的影响，研究其温热药性与温通血脉的作用，揭示温中散寒药的性效本质与科学内涵。方法 实验设空白对照组、模型对照组、附子对照组、10个受试药物组和2个寒 性药对照组，予以灌服寒凉药知母冰水提液复制大鼠胃实寒证模型。模型复制成功后分别灌胃给药，连续3次，分别进行血清促甲状腺激素（TSH）、甲状腺素T3（T3）、甲 状腺素T4（T4）含量检测与肠系膜微循环观察。结果 10个温中散寒药组均能显著升高胃实寒证大鼠TSH、T3、T4含量（P ＜ 0.05，P ＜ 0.01）。显著提高微循环血流速度 和流态（P＜ 0.05，P＜ 0.01）；除荜澄茄、花椒、胡椒组外，其余各给药组还可增加网交数（P＜ 0.05，P＜ 0.01）。结论 温中散寒药通过提高胃实寒证大鼠的甲状腺机 能而体现温热药性，通过改善胃实寒证大鼠的肠系膜微循环而发挥温通血脉作用，缓解阴盛则寒，寒凝血滞状态，发挥治疗胃实寒证的药效。

Objective To observe the effects of Rhizoma Zingiberis，Cortex Cinnamomi，Flos Caryophylli，Fructus Evodiae，Fructus Foeniculi，Rhizoma Alpiniae Officinarum，Fructus Piperis Longi，Fructus Litseae，Pericarpium Zanthoxyli，Fructus Piperis，the ten herbs of warming middle-jiao and dispelling cold on the thyroid function and the mesenterium microcirculation in rats with stomach excess-cold syndrome，thus to investigate the correlation of warm-heat nature with the warming and activating actions. Methods Rats were divided into blank control group，model group，prepared Radix Aconiti group（positive control），two cold-nature herb groups（negative control），and ten warm-heat herb groups. Rat model of stomach excess-cold syndrome was established by intragastric infusion of ice water extract of Rhizoma Anemarrhenae. After the establishment of the model，the rats were given the corresponding medicine orally for 3 continuous days. At the end of the experiment，we tested the serum contents of TSH， T3 and T4，and observed the mesenteric microcirculation. Results The serum contents of TSH，T3 and T4，the microvascular blood flow velocity and flow pattern were increased significantly in the 10 warm-heat herb groups（P＜0.01 or P＜0.05）. Warm-heat herbs except Fructus Litseae，Pericarpium Zanthoxyli and Fructus Piperis also had an effect on increasing the number of crossed vascular nets（P＜ 0.05 or P＜ 0.01）. Conclusion The ten herbs of warming middle-jiao and dispelling cold show the warm nature by improving the thyroid function，and make an effect of warming and activating blood by promote mesenteric microcirculation，thus to cure stomach excess-cold syndrome through relieving exuberant yin-cold and blood stagnation.

R285.5

国家自然科学基金（81060348）。