目的 探讨健脾化瘀解毒复方胃炎I号对胃癌前病变（GPL）的疗效及其分子学机制。方法 将SD大鼠随机分为空白对照组，模型组，维酶素组（ 0.2 g·kg-1），胃炎I号组（7.5 g·kg-1）。采用N-甲基-N’-硝基-N-亚硝基胍（MNNG）水溶液自由饮用、饥饱失常、耗气泻下法复制GPL大鼠模型。观察胃炎I号连续治疗 10周后对GPL 大鼠Wnt信号通路Wnt1、Wnt3a、细胞周期蛋白D1（Cyclin -D1）表达的影响。结果 模型组大鼠胃黏膜上皮的Wnt1、Wnt3a、Cyclin D1表达评分均较空白对照组 显著增加（P＜ 0.05，P＜ 0.01）；胃炎I号能显著拮抗模型组出现的上述变化（P＜ 0.01）。结论 胃炎I号能下调Wnt信号通路Wnt1，Wnt3a，Cyclin D1的表达，抑制Wnt/ β-catenin信号通路的异常激活，能在一定程度上阻断和逆转胃黏膜恶性转变。

Objective To study the effects of Weiyan Recipe 1，which has the actions of strengthening spleen，resolving stasis and removing toxins，on gastric precancerous lesions（GPL），and to explore the related molecular mechanism. Methods SD rats were randomly divided into blank control group，model group，Vitacoenzyme Tablets（0.2 g·kg-1）group，and Weiyan Recipe 1（7.5 g·kg-1）group. The GPL rat model was established by spontaneous intake of N-methyl-N'-nitro-N-nitrosoguanidine（MNNG） solution，irregular diet and intragastric administration of purgative herbs . After treatment for 10 weeks，the expression levels of the upstream regulators Wnt1，Wnt3a and Cyclin D1 in gastric mucosal epithelial cells were observed in all of the groups. Results In contrast with the blank control group，the scores of Wnt1，Wnt3a and Cyclin D1 expression in gastric mucosal epithelial cells of the model group were significantly increased（P＜ 0.05，P＜ 0.01），but decreased dramatically in Weiyan Recipe 1 groups（P＜ 0.01 ）. Conclusion Weiyan Recipe 1 could inhibit the aberrant activation of Wnt/β-catenin signaling pathway through down-regulating the expression of the upstream regulators Wnt1，Wnt3a and Cyclin D1，thus to block or reverse the malignant transformation of gastric mucosa to a certain extent.

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国家自然科学基金项目（81273739）；广东省研究生教育创新计划项目（2013JDXM20）。