目的 观察橘荔散结丸对子宫肌瘤大鼠模型的干预作用和对血液流变学及血清IL-6、TNF-α水平的影响。方法 以雌、孕激素负荷法建立子宫肌瘤的大鼠模型，观察橘荔散结丸对模型大鼠子宫系数、卵巢系数、子宫平滑肌厚度及全血黏度、血清IL-6、TNF-α水平的影响。结果 与模型组比较，橘荔散结丸各治疗组大鼠子宫系数、子宫平滑肌厚度显著下降，卵巢系数上升（P ＜0.01，P ＜0.05），全血高切、中切、低切黏度升高，血浆黏度下降（P ＜0.05）；血清TNF-α水平明显下降（P ＜0.05），血清IL-6水平上升（P ＜0.01）。结论 橘荔散结丸治疗子宫肌瘤的作用机制可能是通过改善血液流变学，调节机体免疫功能，从而达到缩小瘤体的作用。

Objective To study the effect of Juli Sanjie Pill on the hysteromyoma rats，and to observe its influence on blood viscosity and serum IL-6 and TNF-αlevels in rats. Methods The rat model of hysteromyoma was established by the method of estrogen and progesterone load，and the we observed the changes of uterus coefficient，ovary coefficient，uterine smooth muscle thickness，whole blood viscosity and the serum levels of IL-6 and TNF-αin rats of different groups. Results Compared with the model group，the uterus coefficient and uterine smooth muscle thickness were decreased significantly，ovary coefficient was increased，the high-，middle- and low-shear whole blood viscosity and serum IL-6 level were increased significantly，plasma viscosity and serum TNF-αlevel were decreased significantly in Juli Sanjie Pills groups（P ＜0.05，P ＜0.01）. Conclusion The therapeutic mechanism of Juli Sanjie Pill for uterine hysteromyoma may be through improving the blood viscosity and regulating the immune function to reduce tumor mass size.

R285.5

广东省普通高校“中医女性生殖调节与安全性研究”重点实验室开放基金资助项目（ZF201103）。