目的 观察复方虎杖提取物对高脂饲料致高脂血症模型大鼠体质量、血脂水平和动脉硬化指数的影响。方法 采用高脂饲料喂养SD大鼠建立高脂血症模型，灌胃给予复方虎杖提取物低、中、高剂量（4，8，12 g·kg-1），连续8周。分别于给药第2，4，6，8周取血，测血清总胆固醇（TC）、甘油三酯（TG）及高密度脂蛋白胆固醇（HDL-c）、低密度脂蛋白胆固醇（LDL-c）含量及动脉粥样硬化指数（AI）。结果 与模型组比较，复方虎杖提取物灌胃给予大鼠4周后即出现明显降血脂作用，除低剂量组AI外，其余各剂量组TC、TG、LDL-c及AI明显降低（P ＜0.01，P ＜0.05）。给药8周，低剂量组TC、LDL-c及AI明显降低（P ＜0.01）；中剂量组血清TC、LDL-c及AI明显降低（P ＜0.01，P ＜0.05），HDL-c明显升高（P ＜0.05）；高剂量组AI明显降低（P ＜0.01），HDL-c明显升高（P ＜0.05）。结论 复方虎杖提取物4，8，12 g·kg-1 3个剂量组均可以改善高脂饲料致高脂血症模型大鼠的血清血脂水平，具有一定的降血脂作用，且高、中剂量组效果优于低剂量组。

Objective To research the effects of compound Rhizoma Polygoni Cuspidati extract（CRPCE） on body weight，blood lipid levels and atherogenic index of rats with hyperlipidemia induced by high-fat diet. Methods SD rats were fed with high-fat diet for 11 weeks to establish hyperlipidemic model. Body weight was examined before and after modeling. The modeled rats were given intragastric infusion of CRPCE at the dosage of 4，8，12 g·kg-1 respectively for 8 continuous weeks. The blood of rats was sampled on medication week 2，4，6 and 8，and then the serum levels of total cholesterol（TC），triglyceride（TG），high density lipoprotein cholesterol（HDL-c） and low density lipoprotein cholesterol（HDL-c） as well as atherosclerosis index（AI） were measured. Results Compared with the model group，CRPCE showed the hyperlipidemic effect after oral administration for 4 weeks：except for AI in the low-dosage CRPCE group，the contents of TC，TG，LDL-c and AI were decreased all of CRPCE groups（P ＜0.01，P ＜0.05）. On medication week 8，TC，LDL-c and AI were decreased in low- and middle-dosage CRPCE groups（P ＜0.01，P ＜0.05），HDL-c was increased in middle- and high-dosage CRPCE group（P ＜0.05），and AI was decreased in high-dosage CRPCE group（P ＜0.01）. Conclusion CRPCE at the dosage of 4，8，12 g·kg-1 has hypolipidemic effect on improving serum lipid levels of rats with hyperlipidemia induced by high-fat diet，and CRPCE at the dosage of 8，12 g·kg-1 has better hypolipidemic effect.

R285.5

国家重大新药创制专项（2011ZX09102-011-07）；金华市科技计划项目（2011-3-070）。