目的 观察毛冬青对SD大鼠慢性心力衰竭(CHF)炎症相关因子及心功能的影响。方法 将60只雄性SD大鼠随机分为模型组和假手术组，模型组50只，假手术组10只。结扎腹主动脉建立CHF模型，将模型复制成功的大鼠随机分为4组:毛冬青低剂量组，毛冬青高剂量组，卡托普利组和模型组。分别给予毛冬青、卡托普利或生理盐水灌胃，2周后行经胸超声心动图检测，测定血清白介素-1β(IL-1β)和核因子κB(NF-κB)。结果 毛冬青高、低剂量组CHF大鼠血清IL-1β、NF-κB水平明显低于模型组，差异有统计学意义(P ＜ 0.05)。心脏彩超显示:毛冬青高、低剂量组大鼠提高射血分数(EF)和短轴缩短率(FS)与模型组比较差异有统计学意义(P ＜ 0.05)。结论 毛冬青可以改善慢性心力衰竭的炎症状态和心功能。

Objective To observe the effect of Radix Ilecis Pubescentis(RIP) on the inflammation state and heart function in chronic heart failure(CHF) rats. Methods Sixty male SD rats were randomly divided into operation group and sham operation group，operation group had 50 rats，and sham operation group had 10 rats. CHF rat model was established by ligation of abdominal aorta. Rats were randomly divided into 4 groups，low-dose RIP group，high-dose RIP group，captopril group and blank control group，and were given RIP，captopril and normal saline intragastrically. After treatment for 2 weeks，transthoracic ultrasound cardiography was performed，and serum interleukin 1β(IL-1β) and nuclear factor κB(NF- κB) were detected by using enzyme linked immunosorbent assay(ELISA). Results Serum levels of IL-1 β and NF-κB were decreased，and ejection fraction(EF) and shortening fraction(FS) were increased in RIP groups(P ＜ 0.05，compared with those in the blank control groups). Conclusion Radix Ilecis Pubescentis can improve heart function and the inflammatory state of chronic heart failure rats.

广东省中医局建设中医药强省科研课题(2010394)。