目的 观察加味参附颗粒对慢性心力衰竭大鼠的血流动力学、心肌线粒体蛋白浓度及Na+-K -ATP酶、Ca2 -ATP酶活性的影响。方法 雄性SD大鼠50只，随机分为5组:正常对照组，模型组，曲美他嗪组及加味参附颗粒高、低剂量组，每组各10只。采用腹主动脉缩窄法建立心衰模型，预处理8周后，测定心衰大鼠心率、左室内最大上升和下降速率(±dp/dtmax)、血压、心肌线粒体蛋白浓度及Na -K -ATP酶、Ca2 -ATP酶活性。结果 加味参附颗粒高、低剂量组心率、血压均低于模型组(P < 0.05，P < 0.01)，在改善心率方面优于曲美他嗪组(P < 0.05)。加味参附颗粒高、低剂量组±dp/dtmax、心肌线粒体蛋白浓度及Na -K -ATP酶、Ca2 -ATP酶活性均高于模型组(P < 0.05)；与曲美他嗪组比较，差异无统计学意义(P > 0.05)。结论 加味参附颗粒可能通过改善心肌能量代谢，进而改善心衰大鼠血流动力学，提高心肌线粒体蛋白浓度及Na -K -ATP酶、Ca2 -ATP酶活性。

Objective To observe the influence of modified Shenfu granules(MSG) on chronic heart failure rat hemodynamics，myocardial mitochondrial protein concentration and the activities of Na+-K -ATPase，Ca2 -ATPase. Methods Fifty male SD rats were evenly and randomly divided into normal control group，model control group，western medicine group(treated with trimetazidine)，and high-dose and low-dose MSG groups. Rat heart failure model was established by abdominal aortic coarctation method. After treatment for 8 weeks，heart rate，the maximum left ventricular pressure increase and decrease rate(±dp/dtmax)，blood pressure，cardiac mitochondrial protein concentration，and the activities of Na -K -ATPase and Ca2 -ATPase of heart failure rats were measured. Results Heart rate and blood pressure in high，and low-dose MSG groups were lower than those in the model group(P < 0.05，P < 0.01)，and MSG had better effect on improving heart rate than trimetazidine(P < 0.05). High-，and low-dose MSG groups had better effect on increasing ±dp/dtmax)，cardiac mitochondrial protein concentration，and the activities of Na -K -ATPase and Ca2 -ATPase than the model group(P < 0.05)，and the differences had no statistical significance when compared with trimetazidine group(P > 0.05). Conclusion MSG can improve the hemodynamics of heart failure rats，and increase myocardial mitochondrial protein concentration and the activities of Na -K -ATPase through the improvement of myocardial energy metabolism.

广东科技计划课题(2010B030700021)。