目的 考察丁香酚、桂皮醛在药材细粉、挥发油、脂溶性膏剂及β-环糊精包合物、混合物中的稳定性。方法 分别对各样品进行稳定性影响因素试验，采用HPLC法测定丁香酚、桂皮醛含量，计算保留率。结果 强光(6000 lx)照射10 d条件下，丁香酚、桂皮醛在上述不同存在状态下的保留率分别为:77.79 %、95.19 %、63.12 %、69.27 %、0.00 %，91.67 %、89.26 %、63.38 %、66.36 %、0.00 %；高温(60 ℃)受热10 d条件下，丁香酚、桂皮醛在上述不同存在状态下的保留率分别为:83.16 %、93.98 %、77.14 %、80.30 %、23.01 %，4.36 %、90.49 %、64.00 %、84.17 %、24.92 %。结论 丁香酚、桂皮醛在不同存在状态下的光、热不稳定性不同，本研究可为其制剂开发和贮运研究提供参考。

Objective To investigate the stability of eugenol and cinnamaldehyde in powder，volatile oil，fat-soluble ointment，beta-CD inclusion compound and mixture. Methods Stability factors test was conducted for each sample，the content of eugenol and cinnamaldehyde was determined by high performance liquid chromatography(HPLC)，and the retention rate was calculated. Results After light irradiation at 6000 lx for 10 days，eugenol had the retention rate of 77.79 %，95.19 %，63.12 %，69.27 %，0.00 %，and cinnamaldehyde had the retention rate of 91.67 %，89.26 %，63.38 %，66.36 %，0.00 % at different presence states. After heated at temperature of 60 ℃ for 10 days，eugenol had the retention rate of 83.16 %，93.98 %，77.14 %，80.30 %，23.01 %，and cinnamaldehyde had the retention rate of 4.36 %，90.49 %，64.00 %，84.17 %，24.92 % in different presence states. Conclusion The instability of eugenol and cinnamaldehyde varies in different presence states，and the sduty will provide reference for the development of their preparation and storage.

R284.1

穿心莲等中药材规范化种植产业化推广及综合开发利用研究(2011BAI01B01)。