目的 观察丁桂儿脐贴联合用药对功能性消化不良(FD)动物模型胃肠道分泌及运动功能的影响。方法 采用不规则饮食加稀盐酸喂养的方法制备大鼠FD模型，观察丁桂儿脐贴联合用药及丁桂儿口服对FD大鼠胃酸、胃蛋白酶、胃肠激素及胃肠动力的影响。结果 (1)丁桂儿各组对FD大鼠模型胃酸、胃蛋白酶分泌无显著影响(P ＞ 0.05)；(2)丁桂儿脐贴小、中、大剂量联合健胃消食片可显著降低FD模型大鼠血浆CCK-8含量(P ＜ 0.05)，丁桂儿口服组，丁桂儿小、中、大剂量联合健胃消食片组，丁桂儿小、中、大联合莫沙必利组均可显著升高模型大鼠血浆MTL含量(P ＜ 0.01)；(3)丁桂儿脐贴小剂量+莫沙必利组、丁桂儿口服组可显著增强肾上腺素负荷小鼠模型的小肠推进率(P ＜ 0.05)；(4)丁桂儿脐贴小剂量+阿托品组可显著抑制新斯的明负荷小鼠模型的小肠推进率(P ＜ 0.05)，而丁桂儿口服药明显增强新斯的明负荷小鼠模型的小肠推进率(P ＜ 0.05)。结论 丁桂儿脐贴联合用药及单纯口服用药均可通过调节胃肠动力及胃肠激素的分泌缓解FD相关症状。

Objective To observe the influence of Dingguier umbilical paste combined with oral use of medicine and Dingguier tablets on gastrointestinal tract secretion and motor function of functional dyspepsia(FD) model. Methods FD rat model was established by irregular diet and diluted hydrochloric acid feeding. The changes of gastric acid，pepsin，gastrointestinal hormone and gastrointestinal motility were detected to evaluate the effects of Dingguier umbilical paste combined with oral use of medicine and Dingguier tablets. Results (1)No obvious difference of the secretion of gastric acid and pepcin was shown in various Dingguier groups(P ＞ 0.05). (2)The CCK-8 content in FD rat plasma was decreased obviously after using Dingguier umbilical paste combined with Jianwei Xiaoshi tablets(P ＜ 0.05)，and the MTL content in plasma was increased remarkably after oral administration of Dingguier tablets，or external application of Dingguier umbilical paste combined with Jianwei Xiaoshi tablets or mosapride(P ＜ 0.01). (3)Small-dose of Dingguier umbilical paste combined with mosapride，and Dingguier tablets could increase the small intestine propulsion rate of adrenalin-induced mouse model(P ＜ 0.05). (4)Small-dose of Dingguier umbilical paste combined with atropine could restrain the small intestine propulsion rate of neostigmine-induced mouse model(P ＜ 0.05)，but Dingguier tablets could increase the small intestine propulsion rate(P ＜ 0.05). Conclusion Dingguier umbilical paste combined with oral use of medicine and Dingguier tablets could relief the symptoms of FD by regulating the gastrointestinal motility and gastrointestinal hormone.

R285.5

国家重大新药创制项目(2011zx09201-201-35)；山西省自然科学基金(2011011035-5)。