目的 研究凉血通瘀方对实验性瘀热证脑缺血大鼠的治疗作用。方法 大鼠注射大肠杆菌内毒素后，采用插线阻断大鼠中动脉法制备瘀热证脑缺血模型，观察凉血通瘀方对模型大鼠的行为学评分，脑梗死率，血液流变学指标，血清中白细胞介素-1β(IL-1β)、白细胞介素-6(IL-6)，脑组织中一氧化氮(NO)、一氧化氮合酶(NOS)等指标的影响。结果 凉血通瘀方能减轻脑缺血损伤，改善血液流变学指标，降低模型大鼠血清中IL-1β、IL-6含量，抑制脑组织中NOS活性，降低NO含量。结论 凉血通瘀方能减轻瘀热证脑缺血模型大鼠的脑缺血损伤，同时能改善“瘀”、“热”症状。

Objective To investigate the therapeutic effect of Liangxue Tongyu Formula on experimental mixed stasis-heat syndrome of cerebral ischemia in rats. Methods The model was established by middle cerebral artery occlusion(MCAO) after injection with lipopolysaccharide(LPS). The effect of Liangxue Tongyu Formula on behavior grading，ratio of cerebral ischemia，hemorrheologic indexes，serum IL-1β and IL-6 contents，cerebral NO content and NOS activity were evaluated after administration. Results Liangxue Tongyu Formula on significantly reduced the injury of cerebral ischemia，ameliorated hemorrheologic indexes，decreased the serum IL-1β and IL-6 contents，inhibited the cerebral NOS activity and decreased cerebral NO content. Conclusion Liangxue Tongyu Formula not only alleviates the injury of cerebral ischemia but also ameliorate the symptoms of blood stasis and heat syndromes in cerebral ischemia rats with mixed stasis-heat syndrome.

R285.5

国家自然科学基金青年基金(81102885)；江苏省中医药局科技项目(LZ11194)；江苏省自然科学基金(BK2007242)；国家973计划(2006CB504807)。