阿尔兹海默病(Alzheimer’s disease，AD)是以认知功能障碍和记忆损害为主要临床特征的神经退行性疾病，其病因复杂，并缺乏有效的诊断、治疗和预防手段。β淀粉样蛋白(Aβ)被认为是AD治疗的关键靶标。Aβ是AD形成和发展的关键因素，以Aβ为靶标可能是AD预防和治疗的有效策略。中药对减少Aβ 生成和沉积、促进Aβ清除方面已取得了系列的研究成果。中医药治疗AD应创新研究思路，以Aβ为靶标，开展方药配伍、临床试验研究，从而提高中医药治疗AD的疗效。

Alzheimer’s disease(AD) is a progressive neurodegenerative disorder which is characterized bypathological dementia and memory damage in clinic.Due to its complex pathogenesis，there is no effective method for its diagnosis，prevention and treatment. Recently，amyloid β(Aβ)，the key factor of the formation and development of AD，is considered as the possible targeted path of effectively preventing and treating AD. Traditional Chinese medicine has been demonstrated to be effective in reducing Aβ formation and deposition and in promoting Aβ，indicating traditional Chinese medicine can be expected to treat AD more effectively through the research of Aβ-targeted Chinese herbal medicine compatibility and the clinical trial.

R741.02；R285.5

广东省科技计划项目(2010A030100009)；广东省重大科技专项(2012A080202017)；教育部高等学校博士学科点专项科研基金(2011442110007)；广东省高等学校科技创新项目(2012KJCX0032)。