目的 探讨黄连解毒汤及其拆方对高脂高糖模型小鼠血脂及血糖的影响。方法 雄性KM小鼠随机分为黄连解毒汤组、黄连黄柏栀子组、黄连黄柏黄芩组、黄连黄柏组、黄连组、黄芩栀子组、辛伐他汀组、模型组、正常对照组9组。每周测量小鼠体质量，4周后检测小鼠血脂(血清总胆固醇、甘油三酯及血糖)水平。结果 与正常对照组比较，模型组的总胆固醇、甘油三酯及血糖均明显升高，差异有统计学意义(P < 0.01)；与模型组比较，中药各组及辛伐他汀组的总胆固醇、甘油三酯均明显降低，黄连黄柏黄芩组、黄连黄柏组的血糖明显降低(P < 0.01，P < 0.05)；其中黄连黄柏栀子组的总胆固醇、甘油三酯明显低于黄连黄柏黄芩组、黄连黄柏组、黄芩栀子组，差异有统计学意义(P < 0.01)；黄连黄柏栀子组的总胆固醇低于黄连解毒汤组、黄连组，差异有统计学意义(P < 0.05)；黄连解毒汤组、黄连组的总胆固醇均低于黄连黄柏黄芩组、黄连黄柏组、黄芩栀子组，差异有统计学意义(P < 0.05)。各组小鼠在给药前体质量的差异无统计学意义(P > 0.05)，给药4周时黄连黄柏组、辛伐他汀组的体质量低于模型组，差异有统计学意义(P < 0.05)。结论 黄连解毒汤及其拆方组合均有降低高脂高糖模型小鼠总胆固醇、甘油三酯的作用，其中黄连黄柏栀子组的降脂效果优于黄连解毒汤组、黄连黄柏黄芩组、黄连黄柏组、黄连组及黄芩栀子组。黄连黄柏黄芩组及黄连黄柏组能降低高脂高糖饮食小鼠的血糖。

Objective To discuss the influence of Huanglian Jiedu decoction(JID) and its separated recipes on the blood lipid and glucose of hyperlipemia and hyperglycemia model mice. Methods SPF male KM mice were randomly divided into HJD group，Rhizoma Coptidis(Huanglian) group，group of Rhizoma Coptidis and Cortex Phellodendri(Huangbai)，group of Rhizoma Coptidis，Cortex Phellodendri and Radix Scutellariae(Huangqin)，group of Radix Scutellariae and Fructus Gardeniae(Zhizi)，group of Rhizoma Coptidis，Cortex Phellodendri and Fructus Gardeniae，simvastatin group，model group and normal control group. Mice body weight was measured every week，and after 4 weeks the serum total cholesterol(TC) and triglycerides(TG) levels and blood glucose level were detected. Results Compared with the normal control group，TC，TG and blood glucose levels were increased obviously in the model group(P < 0.01). After treatment，TC and TG were decreased in all Chinese herbal medicine groups and simvastatin group，blood glucose was decreased in Huanglian-Huangbai-Huangqin group and Huanglian-Huangbai group when compared with the model group. Huanglian-Huangbai-Zhizi group had lower TC and TG levels than Huanglian- Huangbai-Huangqin group，Huanglian-Huangbai group and Huangqin-Zhizi group(P < 0.01). HJD group and Huanglian group had higher TC than Huanglian-Huangbai-Zhizi group(P < 0.05)，and had lower TC than Huanglian-Huangbai-Huangqin group，Huanglian-Huangbai group and Huangqin-Zhizi group(P < 0.05). The difference of body weight was insignificant among various group before treatment(P > 0.05)，and the body weight in Huanglian-Huangbai group and simvastatin group was lower than that in model group after treatment(P < 0.05). Conclusion HJD and its separated recipes can lower TC and TG levels in hyperlipemia and hyperglycemia model mice，Huanglian-Huangbai-Zhizi recipe has the strongest effect on lowering blood lipid in all of the separated recipes，and Huanglian-Huangbai-Huangqin recipe and Huanglian-Huangbai recipe have an effect on lowering blood glucose .

R285.5

广东省普通高校重点实验室中医病机与治法研究实验室开放课题(2011001214)。