目的 观察昆明山海棠片对银屑病模型动物的治疗作用。方法 采用豚鼠银屑病皮损模型、小鼠阴道上皮细胞有丝分裂模型和小鼠尾部鳞片表皮颗粒层形成模型，观察昆明山海棠片对银屑病各实验动物模型的影响。结果 昆明山海棠片能够降低豚鼠皮损组织白介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)、干扰素-γ(IFN-γ)和细胞间黏附分子-1(ICAM-1)的含量，使豚鼠耳部皮肤角化过度减轻，颗粒层恢复，棘层变薄，表皮突延伸、乳突上伸减轻，炎症细胞浸润减少；能够抑制小鼠阴道上皮细胞的有丝分裂；促进小鼠尾部鳞片表皮颗粒层形成。结论 昆明山海棠片对银屑病模型动物有较好治疗作用。

Objective To study the therapeutic effect of Kunming Shanhaitang tablets on animal model of psoriasis. Methods Guinea pig model of psoriatic lesions，mouse model of mitotic vaginal epithelial cells，and mouse model of tail squamous epidermal granular layer formation were established for the observation of the influences of Kunming Shanhaitang tablets. Results Compared with the model group，Kunming Shanhaitang tablets could remarkably decrease the contents of interleukin-6(IL-6)，tumor necrosis factor alpha(TNF-α)，interferon gamma(IFN-γ) and intercellular adhesion molecule-1(ICAM-1) in psoriatic lesions of guinea pigs，and improve the ear skin pathological changes in hyperkeratesis，granular layer，spinous layer，cuticular process，mastoid process and inflammatory cell infiltration. Kunming Shanhaitang tablets could also inhibit the mitosis of mouse vaginal epithelial cells and promote the formation of mouse tail squamous surface cells.Conclusion Kunming Shanhaitang tablets have certain therapeutic effect on animal model of psoriasis.

R285.5

重庆市科委计划项目(cstc2012pt-kyys1001)；重庆市科委集成示范项目(cstc2013jcsf0118)。