目的 探讨益母草外用的祛湿、止痒功效。方法 建立磷酸组胺致豚鼠皮肤瘙痒模型、右旋糖酐致小鼠瘙痒模型、豚鼠接触性湿疹模型、2，4-二硝基氯苯(DNCB)诱发小鼠迟发型超敏反应模型，观察益母草外用对致痒阈、30 min小鼠瘙痒次数、耳廓肿胀度、湿疹评分的影响，并观察耳组织病理学变化。结果 益母草水煎液或糊剂外用可抑制磷酸组胺引起的瘙痒(P < 0.01)，改善瘙痒症状(P < 0.01，P < 0.05)，抑制豚鼠湿疹耳廓肿胀度(P < 0.01)，改善豚鼠接触性湿疹耳廓组织病理学变化(P < 0.01，P < 0.05)，抑制小鼠迟发型超敏反应模型耳廓肿胀度(P < 0.01)和组织病理学改变(P < 0.01，P < 0.05)。结论 益母草外用具有祛湿、止痒功效。

Objective To investigate the damp-dispelling and itching-relieving effects of Herba Leonuri for external application. Methods We established guinea pig skin pruritus model induced by histamine phosphate，mice dextran-induced pruritus model，guinea pig model of contact eczema，2，4-dinitrochlorobenzol(DNCB) -induced delayed type hypersensitivity mice model，and then observed the effect of external application of Herba Leonuri on itching threshold，itching frequency with 30 min，auricular swelling，eczema scores and pathological changes of the ear tissue. Results External application of the decoction or paste of Herba Leonuri could inhibit itching(P < 0.01)，relieve the symptom of itching(P < 0.01，P < 0.05)，and inhibit auricular swelling(P < 0.01) in guinea pig pruritus model induced by histamine phosphate. Herba Leonuri could also improve the auricular pathological changes of guinea pig contact eczema model(P < 0.01，P < 0.05)，and inhibit auricular swelling(P < 0.01) and auricular pathological changes(P < 0.01，P < 0.05) in DNCB-induced delayed type hypersensitivity mice model. Conclusion Herba Leonuri for external application has damp-dispelling and itching-relieving efficacy.

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国家“十一五”支撑计划课题(2008BAI53B09)；高校科技创新团队项目(2012IRTSTHN011)；河南中医学院科技创新团队计划项目(2010XCXTD0)。