目的 观察胃痞消对慢性萎缩性胃炎癌前病变大鼠NF-κBp65 mRNA表达的影响。方法 SD大鼠随机分为正常对照组，模型组，维酶素组，胃痞消高、中、低剂量组，用1-甲基-3-硝基-1-亚硝基胍溶液(N-methyl-N’-nitro-N-nitrosoguanidine，MNNG)复制慢性萎缩性胃炎(CAG)模型。RT-PCR检测NF-κBp65 mRNA表达。结果 模型组NF-κBp65 mRNA的表达增强，与正常对照组比较差异有统计学意义(P < 0.05)。胃痞消高、中、低剂量组和维酶素组NF-κBp65 mRNA的表达降低，与模型组比较差异有统计学意义(P < 0.05)。结论 胃痞消可以下调胃癌前病变大鼠NF-κBp65 mRNA的表达，从而阻止CAG胃癌前病变的发展。

Objective To observe the influence of Weipixiao on the NF-κBp65 mRNA expression in chronic atrophic gastritis rats with precancerous lesion. Methods SD rats were randomized into normal control group，model group，vitacoenzyme group，and high-，middle- and low-dose Weipixiao groups. N-methyl-N'-nitro-N-nitrosoguanidine was adopted to establish the CAG model，and RT-PCR was used to detect the expression of NF-κBp65 mRNA. Results The expression of NF-κBp65 mRNA was increased in the model group(P < 0.05 compared with that in the normal control group)，and then was decreased in vitacoenzyme group and high-，middle- and low-dose Weipixiao groups(P < 0.05 compared with that in the model group). Conclusion Weipixiao can down-regulate the expression of the NF-κBp65 mRNA in rats with precancerous lesion of gastric carcinoma(PLGC)，so it can prevent the development of PLGC in CAG rats.

R285.5

广东省自然科学基金项目(S2011010003685)。