目的 评价活血灵片对骨科大手术后深静脉血栓形成(DVT)的相关指标血液流变学、血凝时间的影响。方法 将骨科大手术后患者随机分为治疗组(30组)和对照组(30例)，分别给予活血灵片和低分子肝素钙治疗2周，观察2组患者治疗前后全血黏度、血浆黏度、D-二聚体(D-Dimer)、凝血酶原时间(PT)及部分活化凝血活酶时间(APTT)的变化。结果 治疗组术后第14天全血黏度(高切、中切、低切)、血浆黏度均显著下降，明显低于术前、术后第1天(P < 0.05)。治疗组术后第14天D-Dimer显著下降，明显低于术前、术后第1天(P < 0.05)，PT及APTT治疗前后均无明显改变(P > 0.05)。与对照组比较，术后第14天治疗组血液流变学、血凝时间等指标均无统计学意义(P > 0.05)。结论 活血灵片能改善患者骨科大手术后血液流变学，降低D-二聚体，具有预防DVT形成的作用，为防治下肢深静脉血栓形成提供依据。

Objective To observe the effect of Huoxueling tablets on hemorrheologic indexes and clotting time in deep venous thrombosis(DVT) patients after major orthopedic operation. Methods Sixty DVT patients after major orthopedic operation were equally randomized into treatment group and control group, and were treated with Huoxueling tablets and low molecular heparin for 2 weeks, respectively. The changes of whole blood viscosity, plasma viscosity，D-dimer，prothombin time(PT)，and activated partial thromboplastin time(APTT) were observed in both groups before and after treatment. Results The whole high-，middle- and low-shear viscosity，plasma viscosity and D-dimer were obviously decreased in the treatment group on postoperative day 14，which were much lower than those before operation and on the first postoperative day(P < 0.05). PT and APTT in the treatment group showed no obvious change before and after treatment(P > 0.05). Compared with the control group，the difference of hemorrheologic indexes and clotting time in the treatment group was insignificant on postoperative day 14(P > 0.05). Conclusion Huoxueling tablets can improve hemorrheologic indexes and decreasing D-dimer level，which contribute to its mechanism in preventing and treating lower limb DVT after major orthopedic operation.

R285.6

东莞市科技计划医疔卫生类项目(201010515000364)。