目的 优选合成缬沙坦分子印迹聚合物的实验条件。方法 采用正交试验法筛选缬沙坦分子印迹聚合物的合成条件，以结合率和聚合物的硬度为评价指标。结果 优选出制备该聚合物的最佳条件为缬沙坦 ∶ 2-乙烯基吡啶(2-VPY)=1 ∶ 4，2-VPY ∶ 乙二醇二甲基丙烯酸酯(EDMA)=1 ∶ 2.5，(缬沙坦+2-VPY) ∶ 偶氮二异丁腈(AIBN)=1 ∶ 10(mmol ∶ mg)。结论 采用优选的合成条件所制备的聚合物，对模板分子有良好的吸附性能而且硬度合适。

Objective To optimize the conditions for synthesizing the molecularly imprinted polymer(MIP) of valsartan(Val - MIP). Methods With binding ratio and Val-MIP polymer hardness as the evaluation indexes，the preparation conditions of the Val - MIP were optimized by orthogonal experiment. Results The optimal preparation conditions for Val-MIP was as follows:the ratio of Valsartan to 2-VPY being 1∶4，ratio of 2-VPY to EDMA being 1∶2.5，and the ratio of Valsartan and 2-VPY to AIBN being 1∶10. Conclusion The Val- MIP polymer synthesized by the optimized preparation technology has good adsorption performance and appropriate hardness.

R284.1

广东省教育厅项目(2012KJCX0035)；广东省中医院院内研究专项(第二批)(092YTS16)。