目的 观察炉甘石敛口生肌的药效作用。方法 建立深达肌层的大鼠小面积全层皮肤缺损创面模型，观察炉甘石对损伤修复中大鼠体质量、创面直径以及创面肉芽组织的影响。结果 炉甘石有助于缩小创口面积；炉甘石、煅炉甘石在高剂量时均可以促进肉芽组织中的新生毛细血管生成(P < 0.01)，增加受损创面的血供，加速创面恢复。炉甘石高剂量组在给药8 d后，可以增大新生肉芽组织中毛细血管的面积(P < 0.05)；煅炉甘石高剂量组可以增加毛细血管的周长(P < 0.01)。炉甘石、煅炉甘石均可增大肉芽组织中毛细血管管径和增加毛细血管的数量(P < 0.01或P < 0.05)，对新生毛细血管的生长具有明显促进作用。结论 炉甘石、煅炉甘石均能促进大鼠伤口成纤维细胞和毛细血管的形成，加快肉芽组织增生，从而加速皮肤创口的愈合，煅炉甘石生肌作用更强。

Objective To observe the sore-astringing and granulation-promoting action of Calamine. Methods The muscle-layer wounds were produced in rats through surgical operation. The body weight，wound diameter and wound granulation tissue of the rats were investigated during the healing period. Results Raw Calamine was benefit for the reduction of wound area. Raw and calcined Calamine in high dose promoted the formation of neoformative capillaries(P < 0.01)，which could increase the blood supply of the wound and promote its recovery. After medication with high-dose raw Calamine for 8 days，area of capillaries in the granulation tissue was increased(P < 0.05). High-dose calcined Calamine increased the perimeter of the capillaries(P < 0.01). The number and the caliber of the capillaries of the granulation tissue were increased by both raw and calcined Calamine(P < 0.05 or P < 0.01). Conclusion Both raw and calcined Calamine could speed the formation of fibroblast cells and capillaries，promote granulation proliferation，and enhance wound healing. And the calcined Calamine has better effect.

R285.5

江苏省普通高校研究生科研创新计划资助项目(CX09B_2802)。