目的 研究玉叶金花Mussaenda pubescens.的化学成分。方法 采用硅胶、sephadex LH-20、ODS柱色谱等方法进行分离纯化，根据理化性质及波谱数据鉴定化合物的结构。结果 从玉叶金花正丁醇萃取部位分离鉴定了7个三萜皂苷类成分，分别为3β，19α-dihydroxyolean-12-en-28-oic acid(28→1)-β-D-glucopyranosyl ester(1)，mussaendoside R(2)，mussaendoside V(3)，mussaendoside M(4)，mussaendoside Q(5)，mussaendoside G(6)，mussaendoside U(7)。结论 化合物1为首次从该植物中分离得到。

Objective To study the chemical constituents from the whole plants of Mussaenda pubescens. Methods The chemical constituents from the whole plants of Mussaenda pubescens. were isolated and purified by silica column chromatography，ODS and Sephadex LH-20 column chromatography. Their structures were elucidated by chemical and spectral analysis. Results Seven compounds were obtained from n-BuOH-soluble fraction，and they were identified as 3β，19α-dihydroxyolean-12-en-28-oic acid(28→1) -β-D-glucopyranosyl ester(1)，mussaendoside R(2)，mussaendoside V(3)，mussaendoside M(4)，mussaendoside Q(5)，mussaendoside G(6) and mussaendoside U(7). Conclusion Compound(1) has been obtained from the plant of Mussaenda pubescens. for the first time.

R284.1

广西壮族自治区科技厅项目(桂科能12239004-2)。