目的 研究多枝雾水葛提取物对感染诱发皮肤溃疡的治疗作用，并初步探讨其作用机制。方法 建立大鼠细菌性外伤感染皮肤溃疡模型，通过测定大鼠皮肤的脓肿体积、胸腺指数、脾脏指数、血清中肿瘤坏死因子-α(TNF-α)和白细胞介素-1(IL-1)，观察局部病理形态，评价多枝雾水葛提取物对大鼠皮肤溃疡的疗效。结果 多枝雾水葛提取物能显著减轻外伤性溃疡大鼠的脓肿体积(P ＜ 0.05或P ＜ 0.01)，改善局部病理形态，促进溃疡愈合，能明显升高脾脏指数(P ＜ 0.05)，降低大鼠血清中IL-1的含量(P ＜ 0.05)。结论 多枝雾水葛提取物对外伤感染引起的皮肤溃疡具有消肿排脓及促进皮肤愈合作用，其机制可能与抑制炎症因子的释放和调节免疫有关。

Objective To study the therapeutic effect and mechanism of Pouzolzia zeylanica extract on skin ulcers induced by infection with Staphylococcus aureus. Methods Rat skin ulcer model was established by traumatic injury and infection with Staphylococcus aureus. The effects of Pouzolzia zeylanica were evaluated by the parameters of ulcer swelling volume，local pathologic morphology，thymus index and spleen index，tumor necrosis factor (TNF-α) and interleukin(IL-1) content in serum. Results Pouzolzia zeylanica decreased rats ulcer swelling volume(P＜0.05 or P＜0.01)，improved pathologic morphology and promoted ulcer healing. It also obviously increased spleen index(P＜0.05)，and significantly decreased IL-1 content(P＜0.05). Conclusion Pouzolzia zeylanica extract can promote the discharge of pus and detumescence，and promote the healing of skin ulcers induced by trauma infection. Its mechanism may be related with the inhibition of inflammation factors releasing and with regulating immune function.

R285.5

广东省科技厅社会发展资助项目(93039)；国家科技部重大新药创制专项(2011ZX09102-007-03)。