目的 建立药食同源药材中镍的石墨炉原子吸收法，评价茯苓等10种药材中镍的污染状况。方法 前处理采用微波消解和湿法消解两种方式，优化石墨炉升温程序，测定市售药食同源药材中镍的含量。结果 镍的检出限为0.75 ng/mL，精密度RSD为0.90 %，微波消解法的回收率在92.7 % ~ 100.9 %之间，湿法消解的回收率在90.5 % ~99.4 %之间。以3 mg/kg为限量值，药食同源茯苓等10种药材中镍超标23.5 %，药材中镍的每日摄取量是WHO准则规定的耐受摄入量的11.5 %。结论 所建方法快速准确，适合于药材中镍的检测。市售药食同源茯苓等10种药材中镍含量偏高，需引起重视。

Objective A method for the determination of nickel in medicinal and edible Chinese medicinal materials(MECMMs) by Graphite furnace atomic absorption spectrometry(GFAAS) was developed ，and the contamination of nickel was assessed. Methods Microwave digestion and wet digestion procedure were both applied as pretreatment process，and the heating procedure of graphite furnace was optimized to establish an assay method for MECMMs from the market. Results The limit of detection was 0.75 ng/mL and the RSD of precision was 0.90 %. The recoveries employing microwave digestion procedure and wet digestion procedure were in the range of 92.7 %~100.9 % and 90.5 %~99.4 %，respectively. The 23.5 % of samples exceeded 3 mg/kg limit. The daily intake of nickel in MECMMs，was 11.5 % of the tolerance limit recommended by WHO guidelines. Conclusion The method is proved to be rapid，accurate and suitable for the analysis of nickel in medicinal materials. Attention should be paid to the high nickel contamination in medicinal and edible Chinese medicinal materials from the market.

R284.1

科技部创新方法工作专项(2009IM031600)；科技部科技基础性工作专项(2007FY130100)。