目的 考察不同基质和促渗剂对川芎嗪凝胶经皮吸收的影响。方法 采用改良Franz扩散池，以离体裸鼠皮肤为屏障，用HPLC法测定不同基质(1 %卡波姆、5 %CMC-Na、5 %HPMC)和不同促渗剂(氮酮、油酸、冰片和冰片-薄荷脑低共融物)对川芎嗪凝胶的累积渗透量、渗透吸收速率、增渗倍数等参数的影响。结果 以1 %卡波姆为基质时透皮吸收效果最好，几种促渗剂均可较好的促进川芎嗪凝胶的经皮吸收，尤以5 %氮酮以及冰片-薄荷脑(3 % ∶ 3 %)低共融物的促渗效果最佳。结论 1 %卡波姆为最佳的凝胶基质，5 %氮酮或者冰片-薄荷脑(3 % ∶ 3 %)低共融物为川芎嗪凝胶最佳的促渗剂。

Objective To study the effects of different matrices and penetration enhancers on the transdermal absorption of the tetramethylpyrazine(TMP) gel. Methods Improved Franz diffusion cell was adopted as the apparatus for in-vitro nude mouse skin permeation. The kinetic parameters of percutaneous absorption，such as permeability amount，penetration rate and enhancing rate were determined by HPLC. Different matrices(1 % carbopol，5 % CMC-Na，5 % HPMC) and different penetration enhancers such as azone，oleic acid(OA) borneol and borneol-mentholum euctectic mixture were investigated in percutaneous absorption effects. Results The effect of the transdermal absorption of the TMP gel was the best when the matrix was 1 % carbopol. All the penetration enhancers increases the absorption of the TMP gel significantly，in particular 5 % azone and 6 % borneol-mentholum euctectic mixture(3 %∶3 %). Conclusion The optimal matrix is one percent of carbopol，and the optimal penetration enhancer is the five percent of azone or the six percent of borneol-mentholum euctectic mixture(3 %∶3 %).

R285.5