目的 探讨祛风定痛方对小鼠偏头痛模型的作用。方法 复制利血平致低五羟色胺(5-HT)偏头痛模型，观察祛风定痛方对模型小鼠脑组织5-HT水平、凝血时间的影响及其止痛效果。结果 祛风定痛方高、中、低剂量组与模型组比较均能明显升高利血平致低5-HT模型小鼠脑组织中5-HT水平(P < 0.05)，明显延长小鼠凝血时间(P < 0.05，P < 0.01)，有效抑制福尔马林致小鼠疼痛反应，减少小鼠Ⅰ时相舔足时间(P < 0.01)，但不能够减少小鼠Ⅱ时相舔足时间；祛风定痛方能够提高电刺激致大鼠疼痛痛阈，其高剂量组在给药后30，60，90，120 min时与正常对照组比较，差异有统计学意义(P < 0.01)，中剂量组在给药后60，90 min时与正常对照组比较，差异有统计学意义(P < 0.01，P < 0.05)，小剂量组在给药后60 min时与正常对照组比较，差异有统计学意义(P < 0.05)。结论 祛风定痛方治疗偏头痛可能与升高脑组织5-HT水平、延长偏头痛小鼠凝血时间有关，提示其有良好的镇痛作用。

Objective To investigate the effect of Qufeng Dingtong Recipe(QDR) on mice migraine. Methods The 5-hydroxytryptamine(5-HT) migraine mice models were induced by reserpine. After the modeling，we observed the effect of QDR on cerebral 5-HT level and clotting time of migraine mice，and also investigated its analgesic action. Results Large-，middle- and small-dose of QDR significantly increased cerebral 5-HT level(P < 0.05)，prolonged the clotting time(P < 0.05，P < 0.01)，relieved the pain induced by formalin，shortened mice licking paw time of phase I(P < 0.01)，but had no effect on the licking time of phaseⅡ. QDR increased the pain threshold induced by electric stimulation，and the effect of large-dose QDR group 30，60，90，120 min after the medication differed from that in the blank control group(P < 0.01). Middle-dose QDR increased the threshold of pain in 60，90 min(P < 0.01，P < 0.05) and small-dose QDR increased the threshold of pain in 60 min compared with the blank control group(P < 0.05). Conclusion The therapeutic mechanism of QDR for migraine is probably related with the increase of cerebral 5-HT level，prolongation of clotting time and enhancement of analgesic action.

R285.5