目的 观察白芍总苷(TGP)对非酒精性脂肪性肝病(NAFLD)大鼠及脂肪因子apelin和visfatin的影响。方法以果糖-高脂诱导非酒精性脂肪性肝病大鼠模型，模型大鼠随机分为模型组，二甲双胍组(200 mg·kg-1)，TGP高、低剂量组(200，100 mg·kg-1)，另设正常对照组。用药4周后观察各组大鼠空腹血糖(FBG)、胰岛素(Fins)、胰岛素敏感指数(ISI)、胆固醇(TC)、低密度脂蛋白胆固醇(LDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、游离脂肪酸(FFA)、apelin-36、visfatin、天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)、谷胱甘肽转移酶(GST)和肝脏指数。结果TGP高、低剂量组FBG、Fins、LDL-C、TG、apelin-36和visfatin均明显降低，ISI和HDL-C含量明显升高(P < 0.01或P < 0.05)，TGP高剂量组能显著降低ALT、AST和GST的活性及肝脏指数(P < 0.01)，TGP低剂量也能显著降低AST和GST的活性(P < 0.01)及肝脏指数(P < 0.05)。结论TGP能改善果糖-高脂诱导NAFLD大鼠糖脂代谢异常及拮抗胰岛素抵抗，增强胰岛素敏感性，下调apelin和visfatin的表达，改善肝功能。

Objective To investigate total glucosides of paeongy(TGP) on apelin and visfatin in rats with nonalcoholic fatty liver disease(NAFLD). Methods SD rats were divided into normal group，model group(NAFLD)，metformin group(MET，200 mg·kg-1)，high-dose TGP group(TGP-H，200 mg·kg-1) and low-dose TGP group(TGP-L，100 mg·kg-1). NAFLD rat model was induced by fructose and high-fat feeding. After treatment for 4 weeks，all the rats were executed for the examination of serum fasting blood glucose(FBG)，fasting insulin(Fins)，insulin sensitivity index(ISI)，total cholesterol(TC)，low-density lipoprotein cholesterol(LDL-C)，high-density lipoprotein cholesterol(HDL-C)，triglyceride(TG)，free fatty acids(FFA)，apelin-36，visfatin，alanine aminotransferase(ALT)，aspartate aminotransferase(AST)，glutathione transferase(GST) levels and liver index. Results In both TGP-H group and TGP-L group，the levels of FBG，Fins，TG，LDL-C，apelin-36 and visfatin were decreased，but ISI and HDL-C were increased(P < 0.01 or P < 0.05). The activities of ALT，AST，and GST as well as the liver index were reduced by TGP-H(P < 0.01). The AST and GST activities and the liver index were also reduced by TGP-L(P < 0.01 or P < 0.05). Conclusion TGP could improve the disordered lipid metabolism and insulin resistance，enhance insulin sensitivity，down-regulate apelin and visfatin expression，and ameliorate liver function in rats with NAFLD induced by fructose and high-fat feeding.

R285.5