目的探讨姜酚对牛II型胶原诱导性关节炎(Collagen Induced Arthritis，CIA)大鼠的抗炎作用及其机制。方法将6周龄雌性Wistar大鼠随机分为空白对照组、模型组、姜酚组和雷公藤多苷组，每组10只。制备CIA模型，观察姜酚对CIA大鼠关节病理、关节炎指数的变化及对大鼠血清肿瘤坏死因子-α(TNF-α)、白介素-1(IL-1)、白介素-1β(IL-1β)表达的影响。结果姜酚能够抑制CIA大鼠踝关节肿胀，降低关节炎指数，并能降低血清TNF-α、IL-1及IL-1β水平，减轻关节滑膜细胞增生、滑膜层及滑膜下层淋巴细胞浸润，其疗效与雷公藤多苷组相当(P > 0.05)。结论姜酚对CIA大鼠关节炎具有治疗作用，其机制可能与下调TNF-α、IL-1和IL-1β有关。

Objective To study the anti-inflammatory effect and mechanism of gingerol on collagen-induced arthritis in rats. Methods Forty 6-week-aged females Wistar rats were randomly divided into 4 groups，blank group，model group，gingerol treatment group and tripterygium glycosides control group. Rat CIA model was established for the observation of the effect of gingerol on CIA rat ankle pathology，arthritis index and serum tumor necrosis factor alpha(TNF-α)，interkeukin 1(IL-1)，and IL-1 β levels in rats. Results Gingerol could inhibit the swelling of ankle joint of CIA rats，reduce arthritis index，and decrease the serum levels of TNF- α，IL-1 and IL-1β，and significantly relieve the synovial cells proliferation and lymphocyte infiltration in synovial layer and synovial underlayer，which was similar to tripterygium glycosides(P > 0.05). Conclusion Gingerol has remarkable curative effect on CIA in rats，and the therapeutic mechanism may be related with the down-regulation of serum inflammation factors levels of TNF-α，IL-1 and IL-1 β in CIA rats.

R285.5

贵州省中医药管理局项目(QZYY2011-20)；贵州省中医药民族医药重点学科项目(2011年)。