目的 观察归芪通乳合剂对缺乳大鼠模型血清催乳素(PRL)、雌二醇(E2)、多巴胺(DA)水平的影响，探讨其催乳机制。方法建立溴隐亭诱导的大鼠缺乳模型，采用酶联免疫法检测归芪通乳合剂对缺乳大鼠血清PRL、E2、DA水平的影响。结果与溴隐亭缺乳大鼠模型组比较，归芪通乳合剂各剂量组能显著提高溴隐亭缺乳大鼠血清PRL、E2含量(P < 0.05)，降低DA的水平(P < 0.05)。结论归芪通乳合剂催乳机制与提高PRL、E2含量及降低DA的水平有关。

Objective To observe the effect of Guiqi Tongru Mixture on serum prolactin，estradiol and dopamine in rats with postnatal lack of lactation. Methods Rat model of postnatal lack of lactation was induced by bromocriptine. The expression of serum prolactin，estradiol and dopamine in the model rat was detected by enzyme-linked immunosorbent assay. Results Compared with the model group，the serum prolactin and estradiol contents of Guiqi Tongru Mixture groups were increased significantly(both P < 0.05)，while the dopamine expression level was decreased significantly(P < 0.05). Conclusion The lactagogue mechanism of Guiqi Tongru Mixture may be related to its increase of prolactin and estradiol contents and to its inhibition of dopamine expression.

R285.5

重庆市科技计划项目(2010GGD057)。