了解目前欧洲五维健康量表（EQ-5D）在中医药领域卫生经济学研究方面的应用状况和存在问题。 方法系统检索PubMed、Embase、中国知网（CNKI）、中国生物医学文献数据库（CBM）和万方数据库，纳入包 含EQ-5D 分析内容的“中药”“推拿”“针刺”等中医药领域的临床研究文献。采用事先制订的Excel 电子表 格进行数据提取，提取信息包括：题目、发表年份、作者、单位、国家、利益冲突（有无声明或者有无企业参 与）、研究类型、研究对象、干预措施、结局指标、研究角度及测量方法等信息。采用卫生经济学研究质量评 价量表（Quality of health economic studies，QHES）对纳入文献进行方法学质量评价。采用SPSS 18.0 软件对提取 的数据进行描述性分析。结果共纳入52 篇文献，研究设计以随机对照试验为主。EQ-5D-5L 的应用少于 EQ-5D-3L，大部分文献共同使用了效用值和质量调整生命年（Quality-adjusted life years，QALYs）进行成本-效 用分析（Cost-utility analysis，CUA）。肌肉骨骼系统疾病研究使用EQ-5D 较多，中成药和针刺是最常研究的干 预手段；中成药在大部分系统疾病中均有应用，但主要应用在肌肉骨骼系统疾病，与推拿应用的比例相当。针 刺是肌肉骨骼系统疾病中应用最为广泛的干预措施，其次是对疼痛类疾病的应用。根据QHES 评价标准，可获 取全文的37 篇文献的平均得分为73.49 分，其中有20 篇文献属于高质量研究，14 篇为一般质量，3 篇为低 质量。研究质量总体尚可，但存在研究时限选择、研究结果解释、利益冲突、研究角度、效用值及QALYs 的 评价存在不合理或未报告等问题。所有企业参与的研究均未进行利益冲突声明。结论中医药领域卫生经济学 评价中对EQ-5D 的应用偏少，文献质量仍有待提高，该领域研究应用EQ-5D 仍有较大的空间。

To investigate the current application of the EQ-5D in health economics research in the field of traditional Chinese medicine （TCM）. Methods PubMed， Embase， CNKI， CBM and Wanfang databases were systematically searched. The clinical research literature in the field of TCM such as ‘Chinese medicine’，‘tuina’ and‘acupuncture’ containing EQ-5D analysis was included. The Excel spreadsheet was used for data extraction， and the extracted information including title， publication year， author， institution， country， conflicts of interest （declaration or involvement of enterprise） ， study type， participants， interventions， outcomes， research perspectives and measurement methods. The Quality of Health Economic Studies （QHES） was used to evaluate the methodological quality of the included literature. SPSS 18.0 software was used for descriptive analysis of the extracted data. Results A total of 52 articles were included，and the study design was mainly based on randomized controlled trials. The application of EQ-5D-5L was less than that of EQ-5D-3L. Most of the literature used utility value and quality-adjusted life years （QALYs） for cost-utility analysis （CUA） . EQ-5D was widely used in the study of musculoskeletal diseases，and Chinese patent medicine and acupuncture were the most commonly used interventions. Chinese patent medicine was used in most systemic diseases， but it was mainly used in musculoskeletal system diseases， which was equivalent to the proportion of massage application. Acupuncture was the most widely used intervention in musculoskeletal diseases， followed by the application of pain diseases. According to the QHES evaluation criteria，the average score of the 37 articles with full text was 73.49. Among them，20 articles were of high quality，14 articles were of general quality，and 3 articles were of low quality. The quality of the research was generally acceptable， but there were problems such as unreasonable or unreported research time limit selection， research result interpretation， conflict of interest， research perspective， utility value and QALYs evaluation. No conflict of interest statement was made in all the studies involving enterprises. Conclusion The application of EQ-5D in the evaluation of health economics in TCM is less，and the quality of literature still needs to be improved. There is still much room for research and application of EQ-5D in this field.

R195；R2

十三五”国家重点研发计划项目（2018YFC1707407）。