目的 研究黄皮叶对链脲佐菌素（STZ）诱导的糖尿病模型大鼠的降血糖作用及其机制。方法 大鼠随机分6组，即正常对照组，模型组，黄皮叶高、中、低剂量组及格列本脲组。除正常对照组外，其余各组大鼠腹腔注射STZ复制2型糖尿病模型，分别给予溶媒、黄皮叶及格列本脲进行干预，观察黄皮叶对2型糖尿病大鼠空腹血糖值（FBG）、葡萄糖耐受量、血清胰岛素水平、血脂指标、氧化应激的影响以及胰腺的病理变化。结果 黄皮叶可明显降低2型糖尿病模型大鼠FBG水平，提高口服葡萄糖的耐受性，提高胰岛素水平，降低血脂的含量，同时能升高模型大鼠血清中超氧化物歧化酶（SOD）、过氧化氢酶（CAT）和谷胱甘肽（GSH）活性并降低丙二醛（MDA）、一氧化氮（NO）的含量，缓解胰腺病理变化。结论 黄皮叶具有降糖调脂作用，可能与其促胰岛素分泌和抗氧化作用有关。

Objective To study the anti-diabetic effect and mechanism of Folium Clausenae Lansii（FCL） on streptozocin（STZ） -induced diabetic rats. Methods Rats were randomized into 6 groups，namely normal control group，model group，glibenclamide group，and high-，medium- and low-dose FCL groups. Except for the normal control group，rats in other groups were given intraperitoneal injection of STZ to induce type 2 diabetes，and then were given solvent，glibenclamide，high-，medium- and low-dose FCL respectively according to the grouping. Effects of FCL on fasting blood glucose（FBG），oral glucose tolerance test（OGTT），fasting insulin（FINS），lipid parameters，oxidative stress，and histological features of pancreatic tissue were investigated. Results FCL could decrease the content of FBG and blood lipid levels，increase oral glucose tolerance and FINS level，enhance serum superoxide dismutase（SOD），hydrogen peroxidase（CAT） and glutathione（GSH） activities，reduce malondialdehyde（MDA）and nitric oxide（NO） contents ，and relieve the pathological changes of pancreatic gland. Conclusion FCL has obvious anti-diabetic and anti-hyperlipidemia effects on diabetic rats，and the mechanism may be related with the enhancement of insulin secretion and antioxidant effect.

R285.5

广州中医药大学中医药科研创新基金项目（KAB204112K63）；广东省高等学校科技创新重点项目（cxzd1138）。