目的 薏苡仁油属于不饱和脂肪酸，易氧化变质，用β-环糊精（β-CD）包合技术将薏苡仁油包合，使其粉末化。并考察其包合比。方法 用饱和水溶液法制备薏苡仁油β-环糊精包合物，用均匀设计表U7（73）初步确定包合条件，用正交试验表L9（34）得到最佳包合条件，采用差示扫描量热分析、X-射线衍射法、红外分光光度法、电镜扫描法验证包合物，并测定包合物的包合比。结果 投料比为1∶8，β-环糊精∶水1∶10，包合温度65 ℃，包合时间18 h；薏苡仁油可与β-环糊精形成1∶1（摩尔比）的包合物，包合常数281.07 mol·L-1。结论 在本研究条件下，薏苡仁油可与β-环糊精形成稳定的包合物，有利于制成固体制剂。

Objective Coix oil is a kind of unsaturated fatty acid，easy to oxidative deterioration. In this study，β-cyclodextrin（β-CD） inclusion technology was used for the preparation of Coix oil，and inclusion ratio was also investigated. Methods With a saturated aqueous solution，we prepared the compound of Coix oil and β-CD .Uniform design table U7（73） was used to initially identify the inclusion conditions. By orthogonal experiment L9（34） we got the optimal conditions for inclusion. By using differential scanning calorimetry，X-ray diffraction method，infrared spectrophotometry，and scanning electron microscopy，the inclusion compound was verified. Meanwhile，the inclusion ratio was measured. Results The optimal inclusion condition was as follows：feed ratio being 1∶8，the ratio of β-CD to water being 1∶10，inclusion temperature at 65 ℃，and inclusion time being 18h. The inclusion compound of Coix oil with β-cyclodextrin at molar ratio of 1∶1 had the inclusion constant of 248.5 L·mol-1. Conclusion Under the optimized condition，inclusion compound of Coix oil and β-CD is stable，and is conducive to make solid preparation.

R284.1

山西省科技攻关项目（2006031202-02）。