[关键词]
[摘要]
山柰酚是天然的黄酮类化合物,可从多种中药材及水果蔬菜中提取,具有药理活性广泛、毒副作用少 的特点。研究表明,山柰酚对多种常见癌症如结肠癌、乳腺癌、白血病等有明显的预防和抑制作用。其主要 通过阻滞细胞周期、抑制侵袭和迁移、诱导细胞凋亡和自噬、抑制有氧糖酵解等来发挥抗肿瘤作用。同时山 柰酚与许多药物联合使用可以发挥协同抗肿瘤、增敏的作用,其纳米制剂治疗肿瘤具有更好的疗效,表明山 柰酚具有很好的临床应用前景。该文综述近年来山柰酚抗肿瘤的药理作用机制的研究进展,为其进一步的研 发提供理论基础和研究思路。
[Key word]
[Abstract]
Kaempferol,a natural flavonoid compound,can be extracted from various traditional Chinese medicine, fruits and vegetables. It possesses effective physiological activity, low toxicity and low side effects. It has been revealed by the research results that kaempferol exhibits obvious preventive and inhibitory effects on many common cancers, such as colon cancer, breast cancer, leukemia, etc. . The anti-tumor effects are mainly exerted by blocking cell cycle, inhibiting invasion and migration, inducing cell apoptosis and autophagy, and inhibiting aerobic glycolysis of tumors. Meanwhile, the combination of kaempferol and many drugs can produce synergistic anti-tumor and sensitizing effects. The nano-preparation of kaempferol has significant curative effect in the treatment of tumor, which indicates that kaempferol has a good clinical application prospect. In this work, the pharmacological research progress for anti-tumor effect of kaempferol in recent years was reviewed. This article aims to provide theoretical basis and research ideas for further research of kaempferol.
[中图分类号]
R285.5
[基金项目]
广东省中医药局面上项目(20222085);广东省教育厅项目(2020KTSCX029);省部共建中医湿证国家重点实验室项目(SZ2021ZZ38)。